2-Hydroxyglutarate

2-hydroxyglutarate (2-HG) is an organic acid produced during normal cellular energy metabolism. Elevated levels in blood may indicate a rare genetic disorder affecting metabolism, such as 2-hydroxyglutaric aciduria, or can be seen in certain cancers. This test helps identify metabolic disorders or underlying malignancies in patients with unexplained symptoms. Abnormal accumulation can cause neurological symptoms, developmental delays, or organ dysfunction depending on severity.