Acetoacetate

Acetoacetate is a ketone body produced when the body breaks down fat for energy, particularly during fasting, low-carbohydrate diets, or in uncontrolled diabetes. This urine test measures acetoacetate levels, which become elevated during ketosis or diabetic ketoacidosis (DKA). Trace amounts may be normal during fasting or dieting, but significant levels warrant evaluation. In diabetic patients, high acetoacetate indicates dangerously elevated blood acid levels requiring emergency treatment. This test helps clinicians monitor metabolic states and detect dangerous conditions in at-risk patients.