Histidine

ChemistryAlso known as: L-HistidineAlso known as: 2-amino-3-(1H-imidazol-4-yl)propanoic acidnmol/mL

Measures the amount of histidine excreted in serum or plasma.

Normal Range
0.2 – 1 nmol/mL
nmol/mL
Abnormal Levels
Consult your provider
Specimen Type
Blood

Why This Biomarker Matters

Abnormal histidine levels may indicate nutritional deficiency, malabsorption, kidney disease, or metabolic disorders affecting amino acid metabolism.

Understanding Your Results

Normal Range

0.2 – 1 nmol/mL

Overview

Histidine is an essential amino acid required for protein synthesis, immune function, and tissue repair. A urine histidine test measures how much histidine your body is excreting, reflecting nutritional intake, protein metabolism, and kidney function. Elevated urinary histidine may indicate excessive protein intake, kidney disease, or rare metabolic disorders. Low levels may suggest nutritional deficiency or malabsorption. This test helps assess amino acid metabolism and nutritional status.

Research & Evidence

100 publications

Sort:
Scalable production and characterization of recombinant pneumococcal histidine triad protein D in Escherichia coli for vaccine development.
Protein Expr Purif · 2026
PMID: 41539420Other
Histidines promote zinc over cadmium binding to the single type 4 metallothionein from Great Millet (Sorghum bicolor).
J Inorg Biochem · 2026
PMID: 41570457Other
Immunoblot-based activity assay for heme-containing histidine kinases.
J Biol Inorg Chem · 2026
PMID: 42053783
Antifungal repurposing of clinical chelator DMSA against Cryptococcus neoformans via laccase and histidine biosynthesis inhibition.
Microb Pathog · 2026
PMID: 41679612
Targeting bacitracin resistance-associated histidine kinase (BraS) in MRSA with isatin and indazole derivatives.
Sci Rep · 2026
PMID: 42056199
Covalent Targeting of Histidine Residues: A Ligand-First Approach.
J Med Chem · 2026
PMID: 42054250
Substrate selectivity of human histidine methyltransferase METTL9.
Protein Sci · 2026
PMID: 42050879
Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape.
RNA Biol · 2026
PMID: 42003422
Revisiting enzyme engineering strategies and reaction mechanisms of lytic polysaccharide monooxygenases (LPMOs).
Crit Rev Biotechnol · 2026
PMID: 41629066
Histidine-Derived N, O-Codoped Porous Carbon Materials as Supercapacitor Electrodes.
Langmuir · 2026
PMID: 42053573

Research data from MEDLINE/PubMed · 100 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

27972-9Primary
Histidine [Units/volume] in Serum or Plasma
[arb'U]/mL
27904-2
Histidine [Moles/volume] in Urine
nmol/mL
2421-6
Histidine [Presence] in Serum or Plasma
2418-2
Histidine [Presence] in Blood
25926-7
Histidine [Moles/volume] in 24 hour Urine
umol/L
2420-8
Histidine [Mass/volume] in Serum or Plasma
mg/dL
25440-9
Histidine [Moles/time] in 24 hour Urine
umol/(24.h)
22717-3
Histidine [Moles/volume] in Specimen
umol/L
9453-2
Histidine [Moles/volume] in Cerebral spinal fluid
umol/L
20645-8
Histidine [Moles/volume] in Serum or Plasma
umol/L
2423-2
Histidine [Mass/volume] in Urine
mg/dL
2422-4
Histidine [Presence] in Urine
26808-6
Histidine [Presence] in 24 hour Urine
27111-4
Histidine [Moles/volume] in Amniotic fluid
umol/dL
2419-0
Histidine [Mass/volume] in Blood
mg/dL
32246-1
Histidine [Moles/volume] in Body fluid
umol/L
32247-9
Histidine [Moles/volume] in Vitreous fluid
umol/L
47643-2
Histidine [Moles/volume] in DBS
umol/L
55874-2
Histidine [Moles/mass] in Hair
umol/g
2424-0
Histidine [Mass/time] in 24 hour Urine
mg/(24.h)
13398-3
Histidine [Mass/volume] in Amniotic fluid
mg/dL

Available Lab Tests

Order tests that measure this biomarker

Amino Acids (Plasma)

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