von Willebrand factor cleaving protease inhibitor
Detects antibodies that inhibit the enzyme responsible for regulating blood clot formation.
Why This Biomarker Matters
Inhibitors of this enzyme can cause life-threatening clotting disorders. Detection is critical for diagnosing and managing thrombotic thrombocytopenic purpura.
Overview
Von Willebrand factor cleaving protease (ADAMTS13) is an enzyme that regulates blood clotting by breaking down von Willebrand factor. This test detects inhibitors—antibodies that block this enzyme—which can cause dangerous blood clots. Elevated inhibitors are associated with thrombotic thrombocytopenic purpura (TTP), a rare but serious clotting disorder. This test helps diagnose TTP and monitor treatment response in affected patients.
Technical Information (LOINC Codes)
Standardized laboratory codes for this biomarker
34590-0Primary40824-5Available Lab Tests
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