Amyotrophic lateral sclerosis with frontotemporal dementia

disorder

SNOMED 1259124000CUI C3888102

Overview

Amyotrophic lateral sclerosis with frontotemporal dementia is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Abnormal shape of upper motor neuron

Very frequent (80-99%)HP:0002127

Frontotemporal dementia

Very frequent (80-99%)HP:0002145

Lower motor neuron manifestations

Very frequent (80-99%)HP:0002366

Apraxia

Frequent (30-79%)HP:0002186

Behavioral changes

Frequent (30-79%)HP:0000708

Degeneration of the lateral corticospinal tracts

Frequent (30-79%)HP:0002314

Deglutition disorder

Frequent (30-79%)HP:0002015

Depression

Frequent (30-79%)HP:0000716

Difficulty articulating speech

Frequent (30-79%)HP:0001260

Distal limb muscle weakness due to peripheral neuropathy

Frequent (30-79%)HP:0002460

Extrapyramidal syndrome

Frequent (30-79%)HP:0002071

Muscle atrophy, generalised

Frequent (30-79%)HP:0003700

Neuronal loss in the cerebral cortex

Frequent (30-79%)HP:0007190

Parkinsonian disease

Frequent (30-79%)HP:0001300

Partial paralysis of legs

Frequent (30-79%)HP:0002385

Progressive cerebellar ataxia

Frequent (30-79%)HP:0002073

Proximal limb muscle weakness

Frequent (30-79%)HP:0003701

Sensory hallucination

Frequent (30-79%)HP:0000738

Weakness due to upper motor neuron dysfunction

Frequent (30-79%)HP:0010549

Abnormal mitochondrial morphology

Occasional (5-29%)HP:0008322

Bilateral nerve deafness

Occasional (5-29%)HP:0008619

Bulbar palsies

Occasional (5-29%)HP:0001283

Extensor plantar responses

Occasional (5-29%)HP:0003487

Generalised brain degeneration

Occasional (5-29%)HP:0002283

Hyporeflexia

Occasional (5-29%)HP:0001265

Impulse control disorders

Occasional (5-29%)HP:0000734

Muscle fasciculation

Occasional (5-29%)HP:0002380

Mutism

Occasional (5-29%)HP:0002300

Perseverative behaviour

Occasional (5-29%)HP:0030223

Supranuclear gaze paralysis

Occasional (5-29%)HP:0000605

Related Conditions

Frontotemporal dementia(parent)

Amyotrophic lateral sclerosis plus syndrome(parent)

Quick Facts

SNOMED CT: 1259124000
UMLS CUI: C3888102
Fully Specified Name: Amyotrophic lateral sclerosis with frontotemporal dementia (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.