Autosomal recessive spastic paraplegia type 35

disorder

SNOMED 764688002CUI C3496228

Overview

Autosomal recessive spastic paraplegia type 35 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Extensor plantar responses

Very frequent (80-99%)HP:0003487

Gait disturbance

Very frequent (80-99%)HP:0001288

Inability to heel walk

Very frequent (80-99%)HP:0009027

Spastic paraplegia

Very frequent (80-99%)HP:0001258

Spasticity of lower limb

Very frequent (80-99%)HP:0002061

Abnormal finger-nose-finger test

Frequent (30-79%)HP:0001310

Ankle clonus

Frequent (30-79%)HP:0011448

Atrophy of the corpus callosum

Frequent (30-79%)HP:0007371

Brainstem atrophy

Frequent (30-79%)HP:0007366

Cognitive deficits

Frequent (30-79%)HP:0100543

Defective or absent horizontal voluntary eye movements

Frequent (30-79%)HP:0000657

Dysdiadochokinesis

Frequent (30-79%)HP:0002075

Dystonic movements

Frequent (30-79%)HP:0001332

Frequent falls

Frequent (30-79%)HP:0002359

Generalised dystonia

Frequent (30-79%)HP:0007325

Intellectual deterioration

Frequent (30-79%)HP:0001268

Lower limb hypertonia

Frequent (30-79%)HP:0006895

Mental-retardation

Frequent (30-79%)HP:0001249

Spastic tetraparesis

Frequent (30-79%)HP:0001285

Thinning of the corpus callosum

Frequent (30-79%)HP:0033725

Anal incontinence

Occasional (5-29%)HP:0002607

Cerebral cortex atrophy

Occasional (5-29%)HP:0002120

Constant urination

Occasional (5-29%)HP:0100515

CPEO

Occasional (5-29%)HP:0000544

Enuresis nocturna

Occasional (5-29%)HP:0010677

Eye of the tiger anomaly of globus pallidus

Occasional (5-29%)HP:0002454

Flaccid neck

Occasional (5-29%)HP:0000467

Hunched back

Occasional (5-29%)HP:0002808

Mask-like facies

Occasional (5-29%)HP:0000298

Peripheral demyelination

Occasional (5-29%)HP:0011096

Related Conditions

Autosomal recessive hereditary spastic paraplegia(parent)

Complicated hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 764688002
UMLS CUI: C3496228
Fully Specified Name: Autosomal recessive spastic paraplegia type 35 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.