Chimeric antigen receptor-T cell therapy-associated cytokine release syndrome

disorder

SNOMED 1230290005CUI C5680162

Overview

Chimeric antigen receptor-T cell therapy-associated cytokine release syndrome is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Abnormality of interleukin secretion

Very frequent (80-99%)HP:0011117

Abnormality of serum cytokine level

Very frequent (80-99%)HP:0011112

Increased inflammatory response

Very frequent (80-99%)HP:0012649

Pyrexia

Very frequent (80-99%)HP:0001945

Tiredness

Very frequent (80-99%)HP:0012378

Hypotension

Frequent (30-79%)HP:0002615

Increased circulating interferon-gamma concentration

Frequent (30-79%)HP:0030356

Increased circulating interleukin 6 concentration

Frequent (30-79%)HP:0030783

Loss of appetite

Frequent (30-79%)HP:0004396

Muscle pain

Frequent (30-79%)HP:0003326

Racing heart

Frequent (30-79%)HP:0001649

Abnormal liver function tests

Occasional (5-29%)HP:0002910

Cardiac arrhythmias

Occasional (5-29%)HP:0011675

Confusion

Occasional (5-29%)HP:0001289

Decreased urine output

Occasional (5-29%)HP:0011037

Diarrhea

Occasional (5-29%)HP:0002014

Excess fluid in lungs

Occasional (5-29%)HP:0100598

Fluid around lungs

Occasional (5-29%)HP:0002202

Heart block

Occasional (5-29%)HP:0012722

High blood bilirubin levels

Occasional (5-29%)HP:0002904

Hypoxemia

Occasional (5-29%)HP:0012418

Increased creatinine

Occasional (5-29%)HP:0003259

Nausea

Occasional (5-29%)HP:0002018

Reduced ejection fraction

Occasional (5-29%)HP:0012664

Systemic capillary leak syndrome

Occasional (5-29%)HP:0030005

Tachypnea

Occasional (5-29%)HP:0002789

Vomiting

Occasional (5-29%)HP:0002013

Acute kidney failure

Very rare (1-4%)HP:0001919

Disseminated intravascular coagulation

Very rare (1-4%)HP:0005521

Respiratory failure

Very rare (1-4%)HP:0002878

Related Conditions

Complication of introduction procedure(parent)

CRS - cytokine release syndrome(parent)

Acute inflammatory disorder(parent)

Immune system complication of procedure(parent)

Quick Facts

SNOMED CT: 1230290005
UMLS CUI: C5680162
Fully Specified Name: Cytokine release syndrome due to chimeric antigen receptor T-cell immunotherapy (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.