Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Decreased serum leptin
Always present (100%)HP:0003292
Obesity
Always present (100%)HP:0001513
Absence of secondary sex characteristics
Very frequent (80-99%)HP:0008187
Decreased proportion of CD4-positive T cells
Very frequent (80-99%)HP:0032218
Decreased serum estradiol
Very frequent (80-99%)HP:0008214
Decreased serum testosterone level
Very frequent (80-99%)HP:0040171
Decreased T-lymphocyte activation
Very frequent (80-99%)HP:0005419
Decreased testicular size
Very frequent (80-99%)HP:0008734
Hyperinsulinemia
Very frequent (80-99%)HP:0000842
Hypoplastic ovary
Very frequent (80-99%)HP:0008724
Increased appetite
Very frequent (80-99%)HP:0002591
Primary amenorrhea
Very frequent (80-99%)HP:0000786
Primary hypogonadism
Very frequent (80-99%)HP:0000815
Early bone maturation
Frequent (30-79%)HP:0005616
Increased triglycerides
Frequent (30-79%)HP:0002155
Insulin-resistant diabetes
Frequent (30-79%)HP:0000831
Orthostatic hypotension due to autonomic dysfunction
Frequent (30-79%)HP:0004926
TSH deficient hypothyroidism
Frequent (30-79%)HP:0008245
Decreased activity of gonads
HP:0000135
Gynaecomastia
HP:0000771
Pneumonia, recurrent
HP:0006532
Recurrent ear infections
HP:0410018
Recurrent URI
HP:0002788
Short penis
HP:0000054
Related Conditions
Quick Facts
- SNOMED CT
- 700150001
- UMLS CUI
- C3554224
- Fully Specified Name
- Congenital leptin deficiency (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 24
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.