Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Appendicular spasticity
Always present (100%)HP:0034353
Extensor plantar responses
Always present (100%)HP:0003487
Pseudobulbar palsy
Always present (100%)HP:0007024
Abnormal shape of upper motor neuron
Very frequent (80-99%)HP:0002127
Abnormality of balance
Very frequent (80-99%)HP:0002141
Corticospinal signs
Very frequent (80-99%)HP:0007256
Increased reflexes
Very frequent (80-99%)HP:0001347
Involuntary muscle stiffness, contraction, or spasm
Very frequent (80-99%)HP:0001257
Muscle weakness
Very frequent (80-99%)HP:0001324
Pseudobulbar behavioural symptoms
Very frequent (80-99%)HP:0002193
Spastic tetraparesis
Very frequent (80-99%)HP:0001285
Spastic walk
Very frequent (80-99%)HP:0002064
Decreased CMAP amplitude
Frequent (30-79%)HP:0033383
Deglutition disorder
Frequent (30-79%)HP:0002015
Loss of ambulation
Frequent (30-79%)HP:0002505
Loss of speech
Frequent (30-79%)HP:0002371
Rigid dysarthria
Frequent (30-79%)HP:0002464
Abnormality of the bladder
Occasional (5-29%)HP:0000014
Muscle atrophy, neurogenic
Occasional (5-29%)HP:0003202
Sensory neuropathy
Occasional (5-29%)HP:0000763
Cerebral cortex atrophy
HP:0002120
Paleness
HP:0000980
Saccadic slow pursuit
HP:0001152
Spasticity of facial muscles
HP:0002491
Spasticity of pharyngeal muscles
HP:0002501
Tongue muscle weakness
HP:0000183
Tongue spasticity
HP:0025747
Quick Facts
- SNOMED CT
- 717964007
- UMLS CUI
- C1853396
- Fully Specified Name
- Juvenile primary lateral sclerosis (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 27
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.