Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Medullary thyroid cancer
Very frequent (80-99%)HP:0002865
Cervical neoplasm
Frequent (30-79%)HP:0032241
Diarrhea
Frequent (30-79%)HP:0002014
Elevated circulating calcitonin concentration
Frequent (30-79%)HP:0003528
Elevated urinary catecholamines
Frequent (30-79%)HP:0011976
Elevated urinary epinephrine level
Frequent (30-79%)HP:0003639
Elevated urinary norepinephrine level
Frequent (30-79%)HP:0003345
Elevated urinary vanillylmandelic acid
Frequent (30-79%)HP:0011978
Enlarged parathyroid glands
Frequent (30-79%)HP:0008208
Excessive, persistent worry and fear
Frequent (30-79%)HP:0000739
Headache
Frequent (30-79%)HP:0002315
Hyperhidrosis
Frequent (30-79%)HP:0000975
Hypertension associated with pheochromocytoma
Frequent (30-79%)HP:0002640
Hypertensive crisis
Frequent (30-79%)HP:0100735
Paleness
Frequent (30-79%)HP:0000980
Palpitations
Frequent (30-79%)HP:0001962
Pheochromocytoma
Frequent (30-79%)HP:0002666
Thyroid C cell hyperplasia
Frequent (30-79%)HP:0011781
Thyroid nodule
Frequent (30-79%)HP:0025388
Abnormal tongue morphology
Occasional (5-29%)HP:0030809
Aganglionic megacolon
Occasional (5-29%)HP:0002251
Belly bloating
Occasional (5-29%)HP:0003270
Cutaneous lichen amyloidosis
Occasional (5-29%)HP:0032346
Disproportionate tall stature
Occasional (5-29%)HP:0001519
Dyschezia
Occasional (5-29%)HP:0002019
Ganglioneuromatosis
Occasional (5-29%)HP:0025151
Hypercalcemia
Occasional (5-29%)HP:0003072
Hypercalciuria
Occasional (5-29%)HP:0002150
Increased serum parathyroid hormone
Occasional (5-29%)HP:0003165
Kidney stones
Occasional (5-29%)HP:0000787
Related Conditions
Benign multiple endocrine neoplasia type 2a(child)
Malignant multiple endocrine neoplasia type 2a(child)
Multiple endocrine neoplasia type 2A(child)
Polyglandular activity in multiple endocrine adenomatosis(parent)
Hereditary disorder of endocrine system(parent)
Hereditary neoplastic syndrome(parent)
Autosomal dominant hereditary disorder(parent)
Quick Facts
- SNOMED CT
- 61808009
- UMLS CUI
- C4048306
- Fully Specified Name
- Multiple endocrine neoplasia, type 2 (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.