Overview
Neuroleptic malignant syndrome is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Treatments & Interventions
Research Evidence
Peer-reviewed studies linked via MeSH term "Neuroleptic Malignant Syndrome" from the MEDLINE/PubMed database.
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Lorazepam in Managing Atypical Neuroleptic Malignant Syndrome: A Systematic Review of Case Reports.
[object Object], [object Object] · West J Emerg Med · 2025
Clozapine as a treatment for catatonia: A systematic review.
[object Object], [object Object], [object Object] et al. · Schizophr Res · 2024
PMID: 36117082Meta-Analysis
What clinical analysis of antipsychotic-induced catatonia and neuroleptic malignant syndrome tells us about the links between these two syndromes: A systematic review.
[object Object], [object Object], [object Object] et al. · Schizophr Res · 2023
PMID: 37599139Meta-Analysis
Antipsychotics for schizophrenia spectrum disorders with catatonic symptoms.
[object Object], [object Object], [object Object] et al. · Cochrane Database Syst Rev · 2022
A systematic review and pooled, patient-level analysis of predictors of mortality in neuroleptic malignant syndrome.
[object Object], [object Object], [object Object] et al. · Acta Psychiatr Scand · 2021
PMID: 34358327Meta-Analysis
HyperCKemia and rhabdomyolysis in the neuroleptic malignant and serotonin syndromes: A literature review.
[object Object], [object Object], [object Object] et al. · Neuromuscul Disord · 2020
PMID: 33250373Meta-Analysis
Neuroleptic malignant syndrome in patients with cancer: a systematic review.
[object Object], [object Object], [object Object] et al. · BMJ Support Palliat Care · 2020
PMID: 32414787Meta-Analysis
A systematic review of sex and age factors in neuroleptic malignant syndrome diagnosis frequency.
[object Object] · Acta Psychiatr Scand · 2017
PMID: 28144982Meta-Analysis
Conundrums in neurology: diagnosing serotonin syndrome - a meta-analysis of cases.
[object Object], [object Object], [object Object] et al. · BMC Neurol · 2016
[The Neuroleptic Malignant Syndrome].
[object Object], [object Object], [object Object] et al. · Fortschr Neurol Psychiatr · 2015
PMID: 26200042Meta-Analysis
Search all PubMed articles for Neuroleptic malignant syndrome
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Autonomic dysregulation
Very frequent (80-99%)HP:0012332
Disturbances of consciousness
Very frequent (80-99%)HP:0004372
Extrapyramidal muscular rigidity
Very frequent (80-99%)HP:0007076
Hyperhidrosis
Very frequent (80-99%)HP:0000975
Mutism
Very frequent (80-99%)HP:0002300
Pyrexia
Very frequent (80-99%)HP:0001945
Deglutition disorder
Frequent (30-79%)HP:0002015
Drooling
Frequent (30-79%)HP:0002307
Elevated circulating creatine phosphokinase
Frequent (30-79%)HP:0003236
Excessive salivation
Frequent (30-79%)HP:0003781
High blood pressure
Frequent (30-79%)HP:0000822
Increased total leukocyte count
Frequent (30-79%)HP:0001974
Metabolic acidosis
Frequent (30-79%)HP:0001942
Muscle spasm
Frequent (30-79%)HP:0003394
Racing heart
Frequent (30-79%)HP:0001649
Tiredness
Frequent (30-79%)HP:0012378
Tremor
Frequent (30-79%)HP:0001337
Abnormal heart rate
Occasional (5-29%)HP:0011675
Abnormal liver function
Occasional (5-29%)HP:0002910
Acute kidney failure
Occasional (5-29%)HP:0001919
Agitation
Occasional (5-29%)HP:0000713
Altered consciousness or cognition
Occasional (5-29%)HP:0031258
Aspiration pneumonia
Occasional (5-29%)HP:0011951
Blood clot in artery of lung
Occasional (5-29%)HP:0002204
Breakdown of skeletal muscle
Occasional (5-29%)HP:0003201
Choreiform movements
Occasional (5-29%)HP:0002072
Coma
Occasional (5-29%)HP:0001259
Dehydration
Occasional (5-29%)HP:0001944
Elevated alkaline phosphatase
Occasional (5-29%)HP:0003155
Encephalopathy
Occasional (5-29%)HP:0001298
Quick Facts
- SNOMED CT
- 15244003
- UMLS CUI
- C0027849
- Fully Specified Name
- Neuroleptic malignant syndrome (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
- Known Treatments
- 4
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.