Obesity due to leptin receptor gene deficiency

disorder

SNOMED 785722006CUI C5191640

Overview

Obesity due to leptin receptor gene deficiency is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Decreased serum leptin

Always present (100%)HP:0003292

Obesity

Always present (100%)HP:0001513

Absence of secondary sex characteristics

Very frequent (80-99%)HP:0008187

Decreased proportion of CD4-positive T cells

Very frequent (80-99%)HP:0032218

Decreased serum estradiol

Very frequent (80-99%)HP:0008214

Decreased T-lymphocyte activation

Very frequent (80-99%)HP:0005419

Decreased testicular size

Very frequent (80-99%)HP:0008734

Decreased testosterone

Very frequent (80-99%)HP:0040171

Gynaecomastia

Very frequent (80-99%)HP:0000771

Hyperinsulinemia

Very frequent (80-99%)HP:0000842

Hyperphagia

Very frequent (80-99%)HP:0002591

Hypoplastic ovary

Very frequent (80-99%)HP:0008724

Primary amenorrhea

Very frequent (80-99%)HP:0000786

Primary hypogonadism

Very frequent (80-99%)HP:0000815

Early bone maturation

Frequent (30-79%)HP:0005616

Emotional lability

Frequent (30-79%)HP:0000712

Increased triglycerides

Frequent (30-79%)HP:0002155

Insulin-resistant diabetes

Frequent (30-79%)HP:0000831

Orthostatic hypotension due to autonomic dysfunction

Frequent (30-79%)HP:0004926

Recurrent URI

Frequent (30-79%)HP:0002788

TSH deficient hypothyroidism

Frequent (30-79%)HP:0008245

Related Conditions

Reproductive system hereditary disorder(parent)

Recessive hereditary disorder (autosomal)(parent)

Hereditary disorder of nervous system(parent)

Hereditary disorder of endocrine system(parent)

Congenital hypogonadotropic hypogonadism(parent)

Severe obesity(parent)

Genetic obesity disorder(parent)

Quick Facts

SNOMED CT: 785722006
UMLS CUI: C5191640
Fully Specified Name: Obesity due to leptin receptor gene deficiency (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 21

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.