Research Evidence
Peer-reviewed studies linked via MeSH term "Ophthalmoplegia, Chronic Progressive External" from the MEDLINE/PubMed database.
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Mutation in3 Gene in Patients with Horizontal Gaze Palsy with Progressive Scoliosis Syndrome: A Systematic Review.
[object Object], [object Object], [object Object] et al. · Int J Environ Res Public Health · 2020
CPEO and KSS differ in the percentage and location of the mtDNA deletion.
[object Object], [object Object], [object Object] et al. · Mitochondrion · 2009
PMID: 19410662Meta-Analysis
Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy.
[object Object], [object Object], [object Object] et al. · Braz J Med Biol Res · 2015
Tetracycline treatment in patients with progressive external ophthalmoplegia.
[object Object], [object Object], [object Object] et al. · Acta Neurol Scand · 2011
PMID: 21649612RCT
[Observation on therapeutic effect of acupuncture combined with western medicine on paralytic strabismus].
[object Object], [object Object], [object Object] et al. · Zhongguo Zhen Jiu · 2008
PMID: 18630533RCT
20 years of ROBO3-related horizontal gaze palsy with progressive scoliosis: a mini-review.
[object Object], [object Object], [object Object] et al. · Neurogenetics · 2025
PMID: 39960500Review
Progressive external ophthalmoplegia.
[object Object], [object Object] · Handb Clin Neurol · 2023
A novel intronic variant in ROBO3 associated with horizontal gaze palsy with progressive scoliosis: case report and literature review.
[object Object], [object Object], [object Object] et al. · J AAPOS · 2023
PMID: 37931836Review
Eyelid ptosis (Blepharoptosis) for the primary care practitioner.
[object Object], [object Object] · Dis Mon · 2020
PMID: 32605719Review
The neuro-ophthalmology of inherited myopathies.
[object Object], [object Object], [object Object] · Curr Opin Ophthalmol · 2019
PMID: 31436541Review
Search all PubMed articles for Progressive external ophthalmoplegia
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
External ophthalmoplegia, progressive
Very frequent (80-99%)HP:0000590
Muscle abnormality related to mitochondrial dysfunction
Very frequent (80-99%)HP:0003800
Abnormal electromyography finding
Frequent (30-79%)HP:0003457
Abnormal mitochondria in muscle tissue
Frequent (30-79%)HP:0008316
Axial muscle weakness
Frequent (30-79%)HP:0003327
Brisk deep tendon reflexes
Frequent (30-79%)HP:0001348
Eyelid ptosis
Frequent (30-79%)HP:0000508
Hypothyroidism
Frequent (30-79%)HP:0000821
Increased blood lactate
Frequent (30-79%)HP:0002151
Mildly elevated creatine kinase
Frequent (30-79%)HP:0008180
Muscle weakness, progressive, proximal
Frequent (30-79%)HP:0009073
Ragged-red muscle fibers
Frequent (30-79%)HP:0003200
Respiratory failure due to muscle weakness
Frequent (30-79%)HP:0002747
Restrictive respiratory disease
Frequent (30-79%)HP:0002091
Depression
Occasional (5-29%)HP:0000716
Mental retardation, mild
Occasional (5-29%)HP:0001256
Related Conditions
Sensory ataxic neuropathy with dysarthria and ophthalmoparesis syndrome(child)
Mitochondrial neurogastrointestinal encephalomyopathy syndrome(child)
Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy(child)
Progressive external ophthalmoplegia, myopathy, emaciation syndrome(child)
Childhood-onset autosomal recessive myopathy with external ophthalmoplegia(child)
Autosomal dominant progressive external ophthalmoplegia(child)
Autosomal recessive progressive external ophthalmoplegia(child)
Progressive external ophthalmoplegia of left eye(child)
Right progressive external ophthalmoplegia(child)
External ophthalmoplegia(parent)
Chronic musculoskeletal disorder(parent)
Chronic nervous system disease(parent)
Chronic disease of ocular adnexa(parent)
Quick Facts
- SNOMED CT
- 46252003
- UMLS CUI
- C0162674
- Fully Specified Name
- Progressive external ophthalmoplegia (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 16
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.