SAPHO syndrome

disorder

SNOMED 60684003CUI C0263859

Overview

SAPHO syndrome is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Research Evidence

Peer-reviewed studies linked via MeSH term "Hyperostosis Syndromes, Acquired" from the MEDLINE/PubMed database.

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A statistical symptomatic evaluation on SAPHO syndrome from 56 cases of confirmed diagnosis and 352 cases of non-SAPHO involvement.

[object Object], [object Object], [object Object] et al. · Clin Rheumatol · 2024

PMID: 38446355Meta-Analysis

Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis.

[object Object], [object Object], [object Object] et al. · Rheumatology (Oxford) · 2023

PMID: 35961032Meta-AnalysisFull text (PMC)

Treatment and monitoring of SAPHO syndrome: a systematic review.

[object Object], [object Object], [object Object] · RMD Open · 2023

PMID: 38151265Meta-AnalysisFull text (PMC)

Response of Different Treatment Protocols to Treat Chronic Non-Bacterial Osteomyelitis (CNO) of the Mandible in Adult Patients: A Systematic Review.

[object Object], [object Object], [object Object] et al. · Int J Environ Res Public Health · 2020

PMID: 32155902Meta-AnalysisFull text (PMC)

Orofacial manifestations of SAPHO syndrome: a systematic review of case reports.

[object Object], [object Object], [object Object] et al. · Clin Rheumatol · 2020

PMID: 32388746Meta-Analysis

Biologics in SAPHO syndrome: A systematic review.

[object Object], [object Object], [object Object] et al. · Semin Arthritis Rheum · 2019

PMID: 29773231Meta-Analysis

Systematic review of the efficacy and adverse events associated with infliximab treatment of hidradenitis suppurativa in patients with coexistent inflammatory diseases.

[object Object], [object Object], [object Object] et al. · J Am Acad Dermatol · 2013

PMID: 24034373Meta-Analysis

[Clinical Observation of Chaihu Guizhi Decoction in Treating SAPHO Syndrome].

[object Object], [object Object], [object Object] et al. · Zhongguo Zhong Xi Yi Jie He Za Zhi · 2017

PMID: 30650500RCT

Serum levels of angiogenic cytokines in psoriatic arthritis and SAPHO syndrome.

[object Object], [object Object], [object Object] · Pol Arch Med Wewn · 2013

PMID: 23711571RCT

Autoinflammatory Bone Diseases.

[object Object], [object Object], [object Object] et al. · Balkan Med J · 2025

PMID: 39757386ReviewFull text (PMC)

Search all PubMed articles for SAPHO syndrome

Research data from MEDLINE/PubMed

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Abnormality of the chest

Very frequent (80-99%)HP:0000765

Arthralgias

Very frequent (80-99%)HP:0002829

Bone overgrowth

Very frequent (80-99%)HP:0100774

Bone pain

Very frequent (80-99%)HP:0002653

Breakdown of bone

Very frequent (80-99%)HP:0002797

Chest pain

Very frequent (80-99%)HP:0100749

Craniofacial osteosclerosis

Very frequent (80-99%)HP:0005464

Inflammation of sharpey fibres

Very frequent (80-99%)HP:0100686

Neoplasia of the skeletal system

Very frequent (80-99%)HP:0010622

Pustules

Very frequent (80-99%)HP:0200039

Synovitis

Very frequent (80-99%)HP:0100769

Abnormal sacroiliac joint morphology

Frequent (30-79%)HP:0100781

Abnormality of the backbone

Frequent (30-79%)HP:0000925

Bone infection

Frequent (30-79%)HP:0002754

Breaking out

Frequent (30-79%)HP:0001061

Joint inflammation

Frequent (30-79%)HP:0001369

Palmoplantar pustules

Frequent (30-79%)HP:0100847

Psoriasiform dermatitis

Frequent (30-79%)HP:0003765

Water retention

Frequent (30-79%)HP:0000969

Blood clot in vein

Occasional (5-29%)HP:0004936

Chronic diarrhoea

Occasional (5-29%)HP:0002028

Cranial nerve paralysis

Occasional (5-29%)HP:0006824

Fat in feces

Occasional (5-29%)HP:0002570

Frequent fractures

Occasional (5-29%)HP:0002757

Inflammation of blood vessel

Occasional (5-29%)HP:0002633

Inflammatory bowel disease

Occasional (5-29%)HP:0002037

Intestinal malabsorption

Occasional (5-29%)HP:0002024

Skin infections, recurrent

Occasional (5-29%)HP:0001581

Skin rash

Occasional (5-29%)HP:0000988

Upset stomach

Occasional (5-29%)HP:0002027

Related Conditions

Arthropathy associated with another disorder(parent)

Acne(parent)

Osteomyelitis(parent)

Synovitis(parent)

Autoinflammatory syndrome(parent)

Quick Facts

SNOMED CT: 60684003
UMLS CUI: C0263859
Fully Specified Name: Synovitis acne pustulosis hyperostosis osteomyelitis syndrome (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.