Overview
Silver disease is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Cavus foot
Always present (100%)HP:0001761
Decreased motor nerve conduction velocity
Always present (100%)HP:0003431
Distal limb muscle weakness due to peripheral neuropathy
Always present (100%)HP:0002460
Impaired distal proprioception
Always present (100%)HP:0006858
Impaired distal tactile sensation
Always present (100%)HP:0006937
Spastic paraplegia
Always present (100%)HP:0001258
Abnormality of the foot musculature
Frequent (30-79%)HP:0001436
Extensor plantar responses
Frequent (30-79%)HP:0003487
Hand muscle atrophy
Frequent (30-79%)HP:0009130
Inability to heel walk
Frequent (30-79%)HP:0009027
Increased reflexes
Frequent (30-79%)HP:0001347
Spastic walk
Frequent (30-79%)HP:0002064
Abnormal motor nerve conduction velocity
Occasional (5-29%)HP:0040131
Ankle weakness
Occasional (5-29%)HP:0031374
Distal muscle atrophy, upper and lower limbs
Occasional (5-29%)HP:0003693
Dropped arches
Occasional (5-29%)HP:0001763
Hand muscle weakness
Occasional (5-29%)HP:0030237
Hip pain
Occasional (5-29%)HP:0030838
Loss of distal sensation
Occasional (5-29%)HP:0002936
Pain under knee cap
Occasional (5-29%)HP:0030839
Postural tremor
Occasional (5-29%)HP:0002174
Split hand
Occasional (5-29%)HP:0001171
Distal sensory loss, especially vibratory sense
HP:0002166
First dorsal interossei muscle atrophy
HP:0003426
First dorsal interossei muscle weakness
HP:0003392
Lower limb muscle weakness
HP:0007340
Spasticity of lower limb
HP:0002061
Thenar muscle atrophy
HP:0003393
Thenar muscle weakness
HP:0003427
Quick Facts
- SNOMED CT
- 230263009
- UMLS CUI
- C2931276
- Fully Specified Name
- Autosomal dominant spastic paraplegia type 17 (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 29
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.