Spastic paraplegia with Paget disease of bone syndrome

disorder

SNOMED 726622002CUI C4511969

Overview

Spastic paraplegia with Paget disease of bone syndrome is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Elevated alkaline phosphatase

Always present (100%)HP:0003155

EMG: neuropathic changes

Always present (100%)HP:0003445

Extensor plantar responses

Always present (100%)HP:0003487

Gait disturbance

Always present (100%)HP:0001288

Lower limb hyperreflexia

Always present (100%)HP:0002395

Muscle weakness, generalised

Always present (100%)HP:0003324

Spastic paraplegia

Always present (100%)HP:0001258

Spastic walk

Always present (100%)HP:0002064

Abnormal skeletal morphology

Very frequent (80-99%)HP:0011842

Arthritic pain

Very frequent (80-99%)HP:0002829

Bone pain

Very frequent (80-99%)HP:0002653

Increased fracture rate

Very frequent (80-99%)HP:0002757

Increased spinal bone density Z-score

Very frequent (80-99%)HP:0004563

Limb fasciculation

Frequent (30-79%)HP:0007289

Tongue fasciculations/fibrillations

Frequent (30-79%)HP:0001308

Related Conditions

Osteitis deformans(parent)

Hereditary disorder of musculoskeletal system(parent)

Chronic musculoskeletal disorder(parent)

Autosomal dominant complex hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 726622002
UMLS CUI: C4511969
Fully Specified Name: Spastic paraplegia with Paget disease of bone syndrome (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 15

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.