Substance / Medication

Alitretinoin

Overview

Active Ingredient
alitretinoin
RxNorm CUI
81864

Indications

1.1 Kaposi’s Sarcoma PANRETIN GEL is indicated for topical treatment of cutaneous lesions in adults with AIDS related Kaposi’s sarcoma (KS). Limitations of Use: 14.1 [see Clinical Studies ()] PANRETIN GEL is not indicated when systemic anti-KS therapy is required (including more than 10 new KS lesions in the prior month, symptomatic lymphedema, symptomatic pulmonary KS, or symptomatic visceral involvement).

Labeler: Advanz Pharma (US) Corp.Updated: 2025-11-25T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

PANRETIN GEL is contraindicated in patients with a known hypersensitivity to retinoids or to any of the ingredients of the product.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of oral alitretinoin in severe oral lichen planus--results of a prospective pilot study.
Kunz M, Urosevic-Maiwald M, Goldinger S M et al. · J Eur Acad Dermatol Venereol · 2016
PMID: 26507685RCT
The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis.
Thyssen J P, Vester L, Grønhøj Larsen C et al. · Br J Dermatol · 2014
PMID: 23909409RCT
Low levels of alitretinoin in seminal fluids after repeated oral doses in healthy men.
Schmitt-Hoffmann A H, Roos B, Sauer J et al. · Clin Exp Dermatol · 2011
PMID: 21443599RCT
Influence of food on the pharmacokinetics of oral alitretinoin (9-cis retinoic acid).
Schmitt-Hoffmann A H, Roos B, Sauer J et al. · Clin Exp Dermatol · 2011
PMID: 21443600RCT
Pharmacokinetic interactions between alitretinoin and ketoconazole or simvastatin or ciclosporin A.
Schmitt-Hoffmann A H, Roos B, Sauer J et al. · Clin Exp Dermatol · 2011
PMID: 21443601RCT
Pharmacokinetics, efficacy and safety of alitretinoin in moderate or severe chronic hand eczema.
Schmitt-Hoffmann A H, Roos B, Sauer J et al. · Clin Exp Dermatol · 2011
PMID: 21443602RCT
Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema.
Bissonnette R, Worm M, Gerlach B et al. · Br J Dermatol · 2010
PMID: 19906075RCT
Alitretinoin versus phototherapy as the first-line treatment in adults with severe chronic hand eczema: the ALPHA RCT.
Wittmann Miriam, Smith Isabelle L, Brown Sarah Tess et al. · Health Technol Assess · 2024
PMID: 39364555ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Alitretinoin (substance)
SNOMED CT
116086005
UMLS CUI
C0281666
RxNorm CUI
81864
Labeler
Advanz Pharma (US) Corp.

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.