Substance / Medication

Alprazolam

Overview

Active Ingredient
alprazolam
RxNorm CUI
596

Indications

Alprazolam tablets are indicated for the: • acute treatment of generalized anxiety disorder (GAD) in adults. • treatment of panic disorder (PD), with or without agoraphobia in adults.

Labeler: PreferredPharmaceuticals Inc.Updated: 2026-02-20T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

• [see Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Foll

Contraindications

When this intervention should not be used

Alprazolam tablets are contraindicated in patients: • [see ] with known hypersensitivity to alprazolam or other benzodiazepines. Angioedema has been reported. • [see ] taking strong cytochrome P450 3A (CYP3A) inhibitors (e.g., ketoconazole, itraconazole), except ritonavir, ,

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

14 trials linked to this intervention

14
Total Trials
2
Recruiting
8
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Alprazolam for essential tremor.
Bruno Elisa, Nicoletti Alessandra, Quattrocchi Graziella et al. · Cochrane Database Syst Rev · 2015
PMID: 26638213Meta-AnalysisFull text (PMC)
Alprazolam for depression.
van Marwijk Harm, Allick Gideon, Wegman Froukje et al. · Cochrane Database Syst Rev · 2012
PMID: 22786504Meta-AnalysisFull text (PMC)
Residual next-day effects of alprazolam on psychomotor performance and simulated driving in healthy normal adults.
Roszkowski Stevie C, Babalonis Shanna, Coe Marion A et al. · Exp Clin Psychopharmacol · 2025
PMID: 39541522RCTFull text (PMC)
Driving impairment and altered ocular activity under the effects of alprazolam and alcohol: A randomized, double-blind, placebo-controlled study.
Aitken Blair, Hayley Amie C, Ford Talitha C et al. · Drug Alcohol Depend · 2023
PMID: 37611483RCT
GABAergic Effects of Etifoxine and Alprazolam Assessed by Double Pulse TMS.
Riebel Marco, von Pappenheim Benedikt, Kanig Carolina et al. · Pharmacopsychiatry · 2023
PMID: 37220781RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Alprazolam (substance)
SNOMED CT
386983007
UMLS CUI
C0002333
RxNorm CUI
596
Labeler
PreferredPharmaceuticals Inc.

Clinical Data

This intervention maps to 9 entities in the Ltrl knowledge graph.

3
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
14
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.