Substance / Medication

Amlodipine

Overview

Active Ingredient
amlodipine
RxNorm CUI
17767
Labeler: Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.Updated: 2025-11-06T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

5.1 • When pregnancy is detected, discontinue Amlodipine and Valsartan as soon as possible. () 5.1 • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. ()

Contraindications

When this intervention should not be used

Do not use in patients with known hypersensitivity to any component. 7 [see Drug Interactions ()]. Do not coadminister aliskiren with amlodipine and valsartan in patients with diabetes

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
In vitro and in silico studies and a systematic literature review of antiglycation properties of amlodipine.
Dańkowska Karolina, Nesterowicz Miłosz, Lauko Kamil Klaudiusz et al. · Sci Rep · 2025
PMID: 41006534Meta-AnalysisFull text (PMC)
Efficacy and Safety of Azelnidipine as an Antihypertensive Compared to Amlodipine: A Systematic Review and Meta-analysis.
Pal Debkumar, Maji Shampa, Maiti Rituparna · High Blood Press Cardiovasc Prev · 2023
PMID: 37768510Meta-Analysis
Evaluation of the Safety and Efficacy of Dual Therapy Perindopril/Amlodipine in the Management of Hypertension. A Systematic Review and Meta-Analysis.
Mostafa Sadek, Shabana Hosam, Khalil Farag et al. · High Blood Press Cardiovasc Prev · 2022
PMID: 36287359Meta-Analysis
Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis.
Yin Jinjin, Mei Zhengrong, Shi Shengying et al. · Arch Gynecol Obstet · 2022
PMID: 35305140Meta-Analysis
Effect of amlodipine on ventricular hypertrophy in hypertension patients: a systematic review and meta-analysis.
Gao Yi, Zhou Di, Yang Ping · Ann Palliat Med · 2021
PMID: 34763438Meta-Analysis
Amlodipine Compared with Benidipine in the Management of Hypertension: A Systematic Review and Meta-Analysis.
Sofy Ahmed Adel, Abdelsattar Ahmed Taha, Mohammed Omar Magdy et al. · High Blood Press Cardiovasc Prev · 2020
PMID: 33001356Meta-Analysis
Anti-hypertensive efficacy of amlodipine dosing during morning versus evening: A meta-analysis.
Luo Yifan, Ren Lixiang, Jiang Mingyan et al. · Rev Cardiovasc Med · 2019
PMID: 31345001Meta-Analysis
Peripheral edema and headache associated with amlodipine treatment: a meta-analysis of randomized, placebo-controlled trials.
Vukadinović Davor, Scholz Sean S, Messerli Franz H et al. · J Hypertens · 2019
PMID: 31107359Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Amlodipine (substance)
SNOMED CT
386864001
UMLS CUI
C0051696
RxNorm CUI
17767
Labeler
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.