Substance / Medication

Becaplermin

Overview

Active Ingredient
becaplermin
RxNorm CUI
115238

Indications

REGRANEX is indicated for the treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply, when used as an adjunct to, and not a substitute for, good ulcer care practices including initial sharp debridement, pressure relief and infection control. Limitations of Use: The efficacy of REGRANEX has not been established for the treatment of pressure ulcers and venous stasis ulcers [see Clinical Studies /14.2)1 and has

Labeler: Lynch Regnerative MedicineUpdated: 2025-06-13T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

REGRANEX is contraindicated in patients with known neoplasm(s) at the site(s) of application.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Cost effectiveness of Becaplermin in the treatment of diabetic foot ulcers in four European countries.
Ghatnekar O, Persson U, Willis M et al. · Pharmacoeconomics · 2001
PMID: 11548912Meta-Analysis
Cost Effectiveness of Becaplermin Gel on Wound Closure for the Treatment of Pressure Injuries.
Gilligan Adrienne M, Waycaster Curtis R, Milne Catherine T · Wounds · 2018
PMID: 29809161RCT
Cost-Effectiveness of Becaplermin Gel on Diabetic Foot Ulcer HealingChanges in Wound Surface Area.
Waycaster Curtis R, Gilligan Adrienne M, Motley Travis A · J Am Podiatr Med Assoc · 2016
PMID: 27049838Observational
A matched cohort study of the risk of cancer in users of becaplermin.
Ziyadeh Najat, Fife Daniel, Walker Alexander M et al. · Adv Skin Wound Care · 2011
PMID: 21173589Observational
Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel).
Victor-Vega Cassandre, Desai Avani, Montesinos M Carmen et al. · Inflammation · 2002
PMID: 11936752Observational
Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin.
Tauveron V, Rosen A, Khashoggi M et al. · Clin Exp Dermatol · 2013
PMID: 23962308Case Report

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Becaplermin (substance)
SNOMED CT
386940001
UMLS CUI
C0379135
RxNorm CUI
115238
Labeler
Lynch Regnerative Medicine

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.