Substance / Medication

Betaine

Overview

Active Ingredient
betaine
RxNorm CUI
1512

Indications

® EnBrace HR 12 12 is indicated in the TREATMENT of vitamin deficiency - specifically vitamin Bdeficiency, and the PREVENTION of vitamin B-cofactor deficiency, l-methylfolate. 9 12 Requirements of vitamin Band/or vitamin Bin excess of normal due to pregnancy can usually be met with oral supplementation.

Labeler: Jaymac Pharmaceuticals, LLCUpdated: 2026-02-10T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
0
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Dietary Choline and Betaine Are Not Associated With the Risk of Type 2 Diabetes. A Systematic Review and Meta-Analysis of Observational Studies.
Sharifi-Zahabi Elham, Mohammadi Sobhan, Hajizadeh-Sharafabad Fatemeh et al. · J Diabetes Res · 2026
PMID: 41496893Meta-AnalysisFull text (PMC)
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations.
Zawieja Emilia, Chmurzynska Agata · Ageing Res Rev · 2025
PMID: 39647584Meta-Analysis
Effects of chronic betaine supplementation on exercise performance: Systematic review and meta-analysis.
Zawieja Emilia, Machek Steven, Zanchi Nelo Eidy et al. · J Sports Sci · 2024
PMID: 39514262Meta-Analysis
Emerging role of osmoprotectant glycine betaine to mitigate heavy metals toxicity in plants: a systematic review.
Sharma Jyoti, Kumar Sandeep, Singh Pooja et al. · Biol Futur · 2024
PMID: 38183566Meta-Analysis
The association between dietary intakes of methionine, choline and betaine and breast cancer risk: A systematic review and meta-analysis.
Van Puyvelde Heleen, Dimou Niki, Katsikari Aikaterini et al. · Cancer Epidemiol · 2023
PMID: 36701983Meta-Analysis
Effects of betaine supplementation on inflammatory markers: a systematic review and meta-analysis of randomised controlled trials.
Xu Jiaoyang, Nie Zizheng, Qiu Xinyi et al. · Int J Food Sci Nutr · 2023
PMID: 37733077Meta-Analysis
Association of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis.
Yang Qinglin, Han Hua, Sun Zhongming et al. · Eur J Clin Invest · 2023
PMID: 37318151Meta-Analysis
Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis.
Ashtary-Larky Damoon, Bagheri Reza, Ghanavati Matin et al. · Crit Rev Food Sci Nutr · 2022
PMID: 33764214Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Betaine (substance)
SNOMED CT
43356007
UMLS CUI
C0005304
RxNorm CUI
1512
Labeler
Jaymac Pharmaceuticals, LLC

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.