Substance / Medication

Capsaicin

Overview

Active Ingredient
capsaicin
RxNorm CUI
1992

Indications

FOR THE TEMPORARY RELIEF OF MINOR ACHES AND PAINS OF MUSCLES AND JOINTS ASSOCIATED WITH ARTHRITIS, SIMPLE BACKACHE, STRAINS, SPRAINS, MUSCLE SORENESS AND STIFFNESS.

Labeler: 1ST MEDX LLCUpdated: 2026-01-08T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Refining capsaicin-induced pain models: A comprehensive analysis of preclinical practices and their translational potential.
Evans Samuel G, Buisman-Pijlman Femke T A, Mustafa Sanam et al. · Neurosci Biobehav Rev · 2026
PMID: 41183689Meta-Analysis
Lactational performance and hematological effects of capsaicin supplementation in dairy cows: A meta-analysis.
Wasson D E, Martins L F, Wall E H et al. · J Dairy Sci · 2024
PMID: 39307549Meta-Analysis
Randomized controlled trials of the effects of capsaicin or menthol on irritable bowel syndrome: a systematic review and meta-analysis.
Fang Qingying, Yu Leilei, Tian Fengwei et al. · Food Funct · 2024
PMID: 39576289Meta-Analysis
Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis.
Wang Jiatong, Zhang Leilani, Zheng Kangyang · Clin Rev Allergy Immunol · 2024
PMID: 39422806Meta-Analysis
Genetic Influence on Capsaicin Tolerance: Precision Nutrition Implications for Obesity Handling.
Ramos-Lopez Omar, Martinez-Aceviz Yesenia, Sobrevilla-Navarro Ana Alondra et al. · Lifestyle Genom · 2024
PMID: 38810602Meta-Analysis
Efficacy and safety of topical capsaicin in the treatment of osteoarthritis pain: A systematic review and meta-analysis.
Tshering Gyem, Posadzki Pawel, Kongkaew Chuenjid · Phytother Res · 2024
PMID: 38761115Meta-Analysis
A Little Pepper-Upper? Systematic Review of Randomized Controlled Studies on Capsaicinoids, Capsinoids, and Exercise Performance.
Sukan-Karaçağıl Betül, Akbulut Gamze, Açar Yasemin et al. · Int J Sport Nutr Exerc Metab · 2023
PMID: 37414405Meta-Analysis
Topical capsaicin for the management of painful diabetic neuropathy: a narrative systematic review.
Goodwin Brandon, Chiplunkar Maanas, Salerno Ryan et al. · Pain Manag · 2023
PMID: 37435696Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Capsaicin (substance)
SNOMED CT
95995002
UMLS CUI
C0006931
RxNorm CUI
1992
Labeler
1ST MEDX LLC

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.