Substance / Medication

Carbamazepine

Overview

Active Ingredient
carbamazepine
RxNorm CUI
2002
Labeler: Northstar Rx LLCUpdated: 2026-02-26T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

WARNINGS SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE WARNINGS PRECAUTIONS LABORATORY TESTS SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING TREATMENT WITH CARBAMAZEPINE. THESE REACTIO

Contraindications

When this intervention should not be used

Carbamazepine should not be used in patients with a history of previous bone marrow depression, hypersensitivity to the drug, or known sensitivity to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc. Likewise, on theoretical grounds it

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

18 trials linked to this intervention

18
Total Trials
1
Recruiting
7
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Evaluation of Carbamazepine and Gabapentin's Safety and Efficacy in Trigeminal Neuralgia Treatment: A Systematic Review and Meta-Analysis.
Yang Yan, Shang Haitao, Han Tao · Comb Chem High Throughput Screen · 2025
PMID: 39995139Meta-Analysis
Safety and efficacy of carbamazepine in the treatment of trigeminal neuralgia: A metanalysis in biomedicine.
Guo M, Shen W, Zhou M et al. · Math Biosci Eng · 2024
PMID: 38872538Meta-Analysis
Pharmacogenetics of Carbamazepine: A Systematic Review on CYP3A4 and CYP3A5 Polymorphisms.
Riffi Rachda, Boughrara Wefa, Chentouf Amina et al. · CNS Neurol Disord Drug Targets · 2024
PMID: 38859787Meta-Analysis
Carbamazepine cutaneous adverse reactions andgene variation in the Chinese population: a systematic review and meta-analysis.
Meng Qingli, Gu Hongyan, Zhang Qinghua et al. · Pharmacogenomics · 2023
PMID: 37503628Meta-Analysis
The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.
Boughrara Wefa, Chentouf Amina · Acta Neurol Belg · 2022
PMID: 35325436Meta-Analysis
Associations of HLA genetic variants with carbamazepine-induced cutaneous adverse drug reactions: An updated meta-analysis.
Biswas Mohitosh, Ershadian Maliheh, Shobana John et al. · Clin Transl Sci · 2022
PMID: 35599240Meta-AnalysisFull text (PMC)
Anti-seizure efficacy and retention rate of carbamazepine is highly variable in randomized controlled trials: A meta-analysis.
Olaciregui-Dague Karmele, Weinhold Leonie, Hoppe Christian et al. · Epilepsia Open · 2022
PMID: 35980668Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Carbamazepine (substance)
SNOMED CT
387222003
UMLS CUI
C0006949
RxNorm CUI
2002
Labeler
Northstar Rx LLC

Clinical Data

This intervention maps to 14 entities in the Ltrl knowledge graph.

9
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
18
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.