Substance / Medication

Ceritinib

Overview

Active Ingredient
ceritinib
RxNorm CUI
1535457

Indications

® [see Dosage and Administration (2.1)] ZYKADIAis indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test.

Labeler: Novartis Pharmaceuticals CorporationUpdated: 2025-12-15T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Application of time-dependent modeling for the exposure-efficacy analysis of ceritinib in untreated ALK-rearranged advanced NSCLC patients.
Lau Yvonne Y, Gu Wen, Ho Yu-Yun et al. · Cancer Chemother Pharmacol · 2019
PMID: 31020351RCT
Effects of meal type on the oral bioavailability of the ALK inhibitor ceritinib in healthy adult subjects.
Lau Yvonne Y, Gu Wen, Lin Tiffany et al. · J Clin Pharmacol · 2016
PMID: 26272586RCT
Antitumor activity and combined inhibitory effect of ceritinib with gemcitabine in pancreatic cancer.
Jamshed Muhammad Babar, Munir Fahad, Shahid Numan et al. · Am J Physiol Gastrointest Liver Physiol · 2020
PMID: 31736340Observational
Durable brain response with pulse-dose crizotinib and ceritinib in ALK-positive non-small cell lung cancer compared with brain radiotherapy.
Dudnik Elizabeth, Siegal Tali, Zach Leor et al. · J Clin Neurosci · 2016
PMID: 26677785Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ceritinib (substance)
SNOMED CT
703146007
UMLS CUI
C3818721
RxNorm CUI
1535457
Labeler
Novartis Pharmaceuticals Corporation

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.