Substance / Medication

Chlorcyclizine

Overview

Active Ingredient
chlorcyclizine
RxNorm CUI
2354

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

63 trials linked to this intervention

63
Total Trials
5
Recruiting
21
With Results

Research Evidence

Published studies and systematic reviews

Sort:
A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.
Koh Christopher, Dubey Preeti, Han Ma Ai Thanda et al. · Antiviral Res · 2019
PMID: 30711416RCTFull text (PMC)
Homochlorcyclizine Dihydrochloride Inhibits Hepatocellular Carcinoma Progression and Cancer Stem Cell Properties.
Wu Jiayi, Fu Xinzhu, Chang Shiyuan et al. · Anticancer Res · 2025
PMID: 41318154Preclinical
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
He Shanshan, Lin Billy, Chu Virginia et al. · Sci Transl Med · 2015
PMID: 25855495PreclinicalFull text (PMC)
Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development.
Enright Brian P, Gu Yi-Zhong, Snyder Ronald D et al. · Birth Defects Res B Dev Reprod Toxicol · 2010
PMID: 21058326Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Chlorcyclizine (substance)
SNOMED CT
56715009
UMLS CUI
C0008183
RxNorm CUI
2354

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
63
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.