Substance / Medication

Cilastatin

Overview

Active Ingredient
cilastatin
RxNorm CUI
2540
Labeler: Merck Sharp & Dohme LLCUpdated: 2025-12-09T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

RECARBRIO is contraindicated in patients with a history of known severe hypersensitivity (severe systemic allergic reaction such as anaphylaxis) to any component of RECARBRIO.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

101 trials linked to this intervention

101
Total Trials
28
Recruiting
8
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of imipenem/cilastatin/relebactam (IMI/CS/REL): a meta-analysis of randomized controlled clinical trials.
Lei Wenjuan, Duan Yan, Xin Mingyan et al. · BMC Infect Dis · 2025
PMID: 41013394Meta-AnalysisFull text (PMC)
Cilastatin protection against cyclosporin A-induced nephrotoxicity: clinical evidence.
Tejedor A, Torres A M, Castilla M et al. · Curr Med Res Opin · 2007
PMID: 17355732Meta-Analysis
Using imipenem and cilastatin during continuous renal replacement therapy.
Cotton Alison, Franklin Bryony Dean, Brett Stephen et al. · Pharm World Sci · 2005
PMID: 16341743Meta-Analysis
GAUCHO - Trial Genicular Artery Embolization Using Imipenem/Cilastatin vs. Microsphere for Knee Osteoarthritis: A Randomized Controlled Trial.
Correa Mateus Picada, Motta-Leal-Filho Joaquim M, Lugokeski Ricardo et al. · Cardiovasc Intervent Radiol · 2022
PMID: 35304614RCT
[Domestic imipenem cilastatin sodium for the treatment of severe aspiration pneumonia, a curative effect observation].
Yin Hai-yan, Ye Xiao-ling, Zhang Rui et al. · Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · 2012
PMID: 23040783RCT
Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.
Lee Lois S, Kinzig-Schippers Martina, Nafziger Anne N et al. · Diagn Microbiol Infect Dis · 2010
PMID: 20851549RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Cilastatin (substance)
SNOMED CT
96058005
UMLS CUI
C0008777
RxNorm CUI
2540
Labeler
Merck Sharp & Dohme LLC

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

8
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
101
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.