Substance / Medication

Clemastine

SNOMED 372744005 UMLS C0008929

Overview

Active Ingredient

clemastine

RxNorm CUI

2578

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Angioedema

Urticaria

Giant urticaria

Nonseasonal allergic rhinitis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

NCT03109288Phase 1/PHASE2Recruiting250 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Effect of Clemastine Fumarate on Perioperative Hemodynamic Instability Mediated by Anaphylaxis During Cardiopulmonary Bypass Surgery.

Tian Lijuan, Liu Yue, Fei Yuda et al. · Med Sci Monit · 2022

PMID: 35651299RCTFull text (PMC)

Randomized control trial of evaluation of Clemastine effects on visual evoked potential, nerve fiber layer and ganglion cell layer complex in patients with optic neuritis.

Moghaddasi Mehdi, Nabovvati Mona, Koushki Amin et al. · Clin Neurol Neurosurg · 2020

PMID: 32145678RCT

Effect of the H-antihistamine clemastine on PACAP38 induced migraine.

Vollesen Luise Haulund, Guo Song, Andersen Malene Rohr et al. · Cephalalgia · 2019

PMID: 30165750RCT

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial.

Green Ari J, Gelfand Jeffrey M, Cree Bruce A et al. · Lancet · 2017

PMID: 29029896RCT

High-performance liquid chromatographic-tandem mass spectrometric method for the determination of clemastine in human plasma.

Horváth Viola, Tolokán Antal, Egresi Andrea et al. · J Chromatogr B Analyt Technol Biomed Life Sci · 2005

PMID: 15664345Observational

Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry.

Tevell Annica, Bondesson Ulf, Törneke Karolina et al. · Rapid Commun Mass Spectrom · 2004

PMID: 15384147Observational

Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorus detection.

Davydova N N, Yasuda S U, Woosley R L et al. · J Chromatogr B Biomed Sci Appl · 2000

PMID: 10985579Observational

Pilot functional magnetic resonance imaging study of clemastine-aided functional recovery on a mouse model of demyelination.

Egimendia Ander, de la Pisa Irati L, Padro Daniel et al. · Neuroprotection · 2025

PMID: 41383521OtherFull text (PMC)

Clemastine mitigates sepsis-induced acute kidney injury in rats; the role of α-Klotho/TLR-4/MYD-88/NF-κB/ Caspase-3/ p-P38 MAPK signaling pathways.

Abdelnaser Mahmoud, Attya Mina Ezzat, El-Rehany Mahmoud A et al. · Arch Biochem Biophys · 2025

PMID: 39608427Preclinical

Clemastine fumarate alleviates endoplasmic reticulum stress through the Nur77/GFPT2/CHOP pathway after ischemia/reperfusion in rat hearts.

He Yuling, Sun Fan, Song Caixuan et al. · Int Immunopharmacol · 2025

PMID: 39929094Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Clemastine (substance)
SNOMED CT: 372744005
UMLS CUI: C0008929
RxNorm CUI: 2578

Clinical Data

This intervention maps to 4 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.