Substance / Medication

Clindamycin

Overview

Active Ingredient
clindamycin
RxNorm CUI
2582

Indications

Clindamycin in 5% dextrose injection is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. BOXED WARNING Clindamycin in 5% dextrose injection is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of antibioti

Labeler: Hikma Pharmaceuticals USA Inc.Updated: 2024-07-18T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

WARNING Clostridioides difficile- C. difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including clindamycin in 5% dextrose injection and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal

Contraindications

When this intervention should not be used

This drug is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin or lincomycin.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

124 trials linked to this intervention

124
Total Trials
8
Recruiting
69
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Self-reported allergy to penicillin and clindamycin administration may be risk factors for dental implant failure: A systematic review, meta-analysis and delabeling protocol.
Edibam Naushad R, Lorenzo-Pouso Alejandro I, Caponio Vito Carlo Alberto · Clin Oral Implants Res · 2023
PMID: 37102260Meta-Analysis
Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials.
Arteagoitia Iciar, Sánchez Fabio Rodríguez, Figueras Amaia et al. · Clin Oral Investig · 2022
PMID: 35235059Meta-AnalysisFull text (PMC)
Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis.
Lamont Ronald F, Nhan-Chang Chia-Ling, Sobel Jack D et al. · Am J Obstet Gynecol · 2011
PMID: 22071048Meta-AnalysisFull text (PMC)
Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris.
Schlessinger Joel, Menter Alan, Gold Michael et al. · J Drugs Dermatol · 2007
PMID: 17668526Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Clindamycin (substance)
SNOMED CT
372786004
UMLS CUI
C0008947
RxNorm CUI
2582
Labeler
Hikma Pharmaceuticals USA Inc.

Clinical Data

This intervention maps to 9 entities in the Ltrl knowledge graph.

9
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
124
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.