Substance / Medication

Clonazepam

Overview

Active Ingredient
clonazepam
RxNorm CUI
2598

Indications

Clonazepam is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks. CLINICAL PHARMACOLOGY : Clinical Trials The efficacy of clonazepam was established in two 6- to 9-week trials in panic disorder pa

Labeler: AvPAKUpdated: 2026-02-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Clonazepam is contraindicated in patients with the following conditions: History of sensitivity to benzodiazepines Clinical or biochemical evidence of significant liver disease Acute narrow angle glaucoma (it may be used in patients with open angle glaucoma who are receiving appropriate therapy).

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

22 trials linked to this intervention

22
Total Trials
1
Recruiting
10
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Clonazepam for the management of sleep disorders.
Raggi Alberto, Mogavero Maria Paola, DelRosso Lourdes M et al. · Neurol Sci · 2023
PMID: 36112279Meta-Analysis
Clonazepam monotherapy for treating people with newly diagnosed epilepsy.
Brigo Francesco, Igwe Stanley C, Bragazzi Nicola Luigi et al. · Cochrane Database Syst Rev · 2022
PMID: 35187637Meta-AnalysisFull text (PMC)
Clonazepam add-on therapy for drug-resistant epilepsy.
Song Lin, Liu Fang, Liu Yao et al. · Cochrane Database Syst Rev · 2020
PMID: 32309880Meta-AnalysisFull text (PMC)
Clonazepam monotherapy for treating people with newly diagnosed epilepsy.
Brigo Francesco, Igwe Stanley C, Bragazzi Nicola Luigi et al. · Cochrane Database Syst Rev · 2019
PMID: 31742671Meta-AnalysisFull text (PMC)
Clonazepam add-on therapy for refractory epilepsy in adults and children.
Song Lin, Liu Fang, Liu Yao et al. · Cochrane Database Syst Rev · 2018
PMID: 29717488Meta-AnalysisFull text (PMC)
Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis.
Cui Y, Xu H, Chen F M et al. · Oral Dis · 2016
PMID: 26680638Meta-Analysis
Clonazepam for neuropathic pain and fibromyalgia in adults.
Corrigan Ruth, Derry Sheena, Wiffen Philip J et al. · Cochrane Database Syst Rev · 2012
PMID: 22592742Meta-AnalysisFull text (PMC)
Clonazepam and lorazepam in acute mania: a Bayesian meta-analysis.
Curtin François, Schulz Pierre · J Affect Disord · 2004
PMID: 15013244Meta-Analysis
Clonazepam repurposing inpatients through conventional RCT and N-of-1 trials: an experimental strategy for orphan disease development.
van der Sluijs Pleuntje J, Safai Pour Koshar, Berends Cécile L et al. · J Med Genet · 2025
PMID: 39740803RCTFull text (PMC)
Differential effects of clonazepam on declarative memory formation and face recognition.
Leon Candela S, Lo Celso Agustina L, Urreta Benítez Facundo A et al. · Neurobiol Learn Mem · 2024
PMID: 38964601RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Clonazepam (substance)
SNOMED CT
387383007
UMLS CUI
C0009011
RxNorm CUI
2598
Labeler
AvPAK

Clinical Data

This intervention maps to 12 entities in the Ltrl knowledge graph.

7
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
22
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.