Substance / Medication

Collagenase

Overview

Active Ingredient
collagenase
RxNorm CUI
58939

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
"Collagenase injections versus limited fasciectomy in treating patients with Dupuytren's contracture: A systematic review and meta-analysis".
Rajpar Najaf Ahmed, Khaskheli Sanya Ashraf, Abbasi Sabahat Ul Ain Munir et al. · Int J Orthop Trauma Nurs · 2025
PMID: 40639262Meta-Analysis
Collagenase clostridium histolyticum injection versus limited fasciectomy for the treatment of Dupuytren's disease: a systematic review and meta-analysis of comparative studies.
Liechti Rémy, Merky Dominique Nellie, Sutter Damian et al. · Arch Orthop Trauma Surg · 2024
PMID: 37665353Meta-Analysis
Efficacy of collagenase Clostridium histolyticum combination therapies for Peyronie's disease: a systematic review and meta-analysis.
Guo Yicheng, Yang Yingying, Mao Qiancheng et al. · Sex Med Rev · 2024
PMID: 38650382Meta-Analysis
Industry Sponsorship Bias in Collagenase Clinical Trials for Dupuytren Disease: A Meta-analysis.
Gray Kelsey M, Khatiwada Priyenka, Capito Anthony E · Ann Plast Surg · 2024
PMID: 38527344Meta-Analysis
Collagenase-producing bacteria are common in anastomotic leakage after colorectal surgery: a systematic review.
Jørgensen Anders Bech, Jonsson Isabella, Friis-Hansen Lennart et al. · Int J Colorectal Dis · 2023
PMID: 38038731Meta-AnalysisFull text (PMC)
Collagenase Treatment Versus Needle Fasciotomy for Single-Digit Dupuytren Contractures: A Meta-Analysis of Randomized Controlled Trials.
Zhang Dafang, Earp Brandon E, Blazar Philip · J Hand Surg Am · 2023
PMID: 37725027Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Collagenase (substance)
SNOMED CT
772213007
UMLS CUI
C0162745
RxNorm CUI
58939

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.