Substance / Medication

Dasatinib

Overview

Active Ingredient
dasatinib
RxNorm CUI
475342

Indications

Dasatinib tablets are indicated for the treatment of adult patients with Dasatinib tablets are indicated for the treatment of pediatric patients 1 year of age and older with newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase. chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including imatinib. Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance o

Labeler: AvKAREUpdated: 2025-11-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

12 trials linked to this intervention

12
Total Trials
10
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity.
Calizo Rhodora C, Bhattacharya Smiti, van Hasselt J G Coen et al. · Nat Commun · 2019
PMID: 31053734Meta-AnalysisFull text (PMC)
Utility of Therapeutic Drug Monitoring of Imatinib, Nilotinib, and Dasatinib in Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis.
García-Ferrer Manuel, Wojnicz Aneta, Mejía Gina et al. · Clin Ther · 2019
PMID: 31812340Meta-Analysis
Major molecular response during the first year of dasatinib, imatinib or nilotinib treatment for newly diagnosed chronic myeloid leukemia: a network meta-analysis.
Signorovitch James, Ayyagari Rajeev, Reichmann William M et al. · Cancer Treat Rev · 2014
PMID: 24112812Meta-Analysis
Rash with the multitargeted kinase inhibitors nilotinib and dasatinib: meta-analysis and clinical characterization.
Drucker Aaron M, Wu Shenhong, Busam Klaus J et al. · Eur J Haematol · 2013
PMID: 23240881Meta-Analysis
Dasatinib and nilotinib for imatinib-resistant or -intolerant chronic myeloid leukaemia: a systematic review and economic evaluation.
Rogers G, Hoyle M, Thompson Coon J et al. · Health Technol Assess · 2012
PMID: 22551803Meta-AnalysisFull text (PMC)
Dasatinib treatment for imatinib resistant or intolerant patients with chronic myeloid leukaemia.
Li J, Xu G, Yu S et al. · J Int Med Res · 2011
PMID: 21672337Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Dasatinib (substance)
SNOMED CT
423658008
UMLS CUI
C1455147
RxNorm CUI
475342
Labeler
AvKARE

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
12
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.