Substance / Medication

Demeclocycline

Overview

Active Ingredient
demeclocycline
RxNorm CUI
3154

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
0
Recruiting
2
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review.
Miell J, Dhanjal P, Jamookeeah C · Int J Clin Pract · 2015
PMID: 26289137Meta-AnalysisFull text (PMC)
Comparative evaluation of methylene blue and demeclocycline for enhancing optical contrast of gliomas in optical images.
Wirth Dennis, Snuderl Matija, Curry William et al. · J Biomed Opt · 2014
PMID: 25239672Observational
Development and validation of a reversed-phase liquid chromatographic method for analysis of demeclocycline and related impurities.
Kahsay Getu, Maxa Jaroslav, Van Schepdael Ann et al. · J Sep Sci · 2012
PMID: 22733511Observational
Long-term Use of Demeclocycline for the Treatment of Chronic Hyponatremia.
Singh Amardeep, Dass Bhagwan, Ejaz Abutaleb et al. · Cureus · 2019
PMID: 31988816Case ReportFull text (PMC)
Irreversible nephrotoxicity from demeclocycline in the treatment of hyponatremia.
Curtis Nicola J, van Heyningen Charles, Turner John J · Age Ageing · 2002
PMID: 11937482Case Report
Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives.
Tourville Aurore, Viguier Sarah, González-Lizárraga Florencia et al. · Antioxidants (Basel) · 2023
PMID: 36978822OtherFull text (PMC)
Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound.
Tomas-Grau Rodrigo, González-Lizárraga Florencia, Ploper Diego et al. · Cells · 2022
PMID: 36078167OtherFull text (PMC)
Anti-nociceptive effects of non-antibiotic derivatives of demeclocycline and doxycycline against formalin-induced pain stimulation.
Nascimento Glauce Crivelaro, Vivanco-Estela Airam Nicole, Ferrié Laurent et al. · Eur J Pharmacol · 2024
PMID: 39393668Preclinical
A randomized phase 2 study on demeclocycline in patients with mild-to-moderate COVID-19.
Iwahori Kota, Nii Takuro, Yamaguchi Norihiko et al. · Sci Rep · 2023
PMID: 37612352TrialFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Demeclocycline (substance)
SNOMED CT
372779007
UMLS CUI
C0011276
RxNorm CUI
3154

Clinical Data

This intervention maps to 19 entities in the Ltrl knowledge graph.

19
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.