Substance / Medication

Deucravacitinib

Overview

Active Ingredient
deucravacitinib
RxNorm CUI
2612087

Indications

SOTYKTU™ is indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. Limitations of Use : SOTYKTU is not recommended for use in combination with other potent immunosuppressants.

Labeler: E.R. Squibb & Sons, L.L.C.Updated: 2022-09-09T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Warnings and Precautions (5.1) [see] SOTYKTU is contraindicated in patients with a history of hypersensitivity reaction to deucravacitinib or to any of the excipients in SOTYKTU.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

7 trials linked to this intervention

7
Total Trials
3
Recruiting
3
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Deucravacitinib for Moderate-to-Severe Psoriasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Toth Otavio A S, Meldola Patrick F, Machado Pablo G et al. · J Drugs Dermatol · 2024
PMID: 38306122Meta-Analysis
Safety and efficacy of Deucravacitinib for moderate to severe plaque psoriasis: A meta-analysis.
Hu Caixia, Han Xiaomei, Cui Yu et al. · Skin Res Technol · 2024
PMID: 39180322Meta-AnalysisFull text (PMC)
Deucravacitinib, a selective, TYK2 inhibitor, in psoriatic arthritis: achievement of minimal disease activity components in a phase 2 trial.
Kavanaugh Arthur, Coates Laura C, Mease Philip J et al. · Rheumatology (Oxford) · 2025
PMID: 39423145RCTFull text (PMC)
Deucravacitinib in plaque psoriasis: 2-year safety and efficacy results from the phase III POETYK trials.
Lebwohl Mark, Warren Richard B, Sofen Howard et al. · Br J Dermatol · 2024
PMID: 38226713RCT
Improvements in Patient-Reported Outcomes After Treatment With Deucravacitinib in Patients With Psoriatic Arthritis: Results From a Randomized Phase 2 Trial.
Strand Vibeke, Gossec Laure, Coates Laura C et al. · Arthritis Care Res (Hoboken) · 2024
PMID: 38529674RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Deucravacitinib (substance)
SNOMED CT
1025321000122103
UMLS CUI
C5420928
RxNorm CUI
2612087
Labeler
E.R. Squibb & Sons, L.L.C.

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
7
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.