Substance / Medication

Diroximel fumarate

Overview

Active Ingredient
diroximel fumarate
RxNorm CUI
2261783

Indications

VUMERITY is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Labeler: Biogen Inc.Updated: 2025-05-29T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

VUMERITY is contraindicated in patients 5.1 [see Warnings and Precautions ()]. With known hypersensitivity to diroximel fumarate, dimethyl fumarate, or to any of the excipients of VUMERITY. Reactions may include anaphylaxis and angioedema 7.1 Drug Interactions ()] Taking dimethyl fumarate [see.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Safety and effectiveness of diroximel fumarate in relapsing forms of multiple sclerosis: a systematic review and meta-analysis.
Sabet Haneen, Zanaty Mohamed Ahmed, Arafa Abdelfattah et al. · Neurol Sci · 2025
PMID: 40229470Meta-AnalysisFull text (PMC)
Matching-adjusted indirect comparisons of diroximel fumarate, ocrelizumab and interferon beta-1a for relapsing multiple sclerosis.
Hersh Carrie M, Aladro-Benito Yolanda, Lewin James B et al. · J Comp Eff Res · 2025
PMID: 40937633ObservationalFull text (PMC)
Real-World Experience with Diroximel Fumarate in Patients with Multiple Sclerosis: A Prospective Multicenter Study.
Aguirre Clara, Alonso-Torres Ana, Agüera Eduardo et al. · Clin Drug Investig · 2024
PMID: 39466585Observational
Diroximel Fumarate in Relapsing Forms of Multiple Sclerosis: A Profile of Its Use.
Paik Julia · CNS Drugs · 2021
PMID: 34057708Observational
Herpes zoster infection in a patient with relapsing-remitting multiple sclerosis treated with diroximel fumarate.
Dempsey John, Balshi Alexandra, Sloane Jacob · BMJ Case Rep · 2025
PMID: 40180342Case Report
Vaginal Herpes Zoster While Under Treatment for Relapsing-Remitting Multiple Sclerosis With Diroximel Fumarate.
Gül Sedat, Ahmed Adeenah F, McGraw Corey · Cureus · 2023
PMID: 37485166Case ReportFull text (PMC)
Effect of diroximel fumarate on gut dysbiosis and autoimmunity in the central nervous system.
Yadav Sudhir Kumar, Ito Naoko, Suresh Shradha et al. · Int Immunopharmacol · 2026
PMID: 41411731Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Diroximel fumarate (substance)
SNOMED CT
1268407006
UMLS CUI
C5139729
RxNorm CUI
2261783
Labeler
Biogen Inc.

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.