Substance / Medication

Doxycycline

Overview

Active Ingredient
doxycycline
RxNorm CUI
3640

Indications

ORACEA is indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. No meaningful effect was demonstrated for generalized erythema (redness) of rosacea. ORACEA has not been evaluated for the treatment of the erythematous, telangiectatic, or ocular components of rosacea. Efficacy of ORACEA beyond 16 weeks and safety beyond 9 months have not been established. This formulation of doxycycline has not been evaluated in the treatment or prevention of

Labeler: Physicians Total Care, Inc.Updated: 2009-12-30T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

This drug is contraindicated in persons who have shown hypersensitivity to doxycycline or any of the other tetracyclines.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

22 trials linked to this intervention

22
Total Trials
1
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies.
Carneiro Bruna Tavares, Prado Marina Minici Dumont, Nogueira Iara de Oliveira et al. · Odontology · 2025
PMID: 39133374Meta-Analysis
Efficacy of Doxycycline as Preexposure and/or Postexposure Prophylaxis to Prevent Sexually Transmitted Diseases: A Systematic Review and Meta-Analysis.
Boschiero Matheus Negri, Sansone Nathália Mariana Santos, Matos Laura Ribeiro et al. · Sex Transm Dis · 2025
PMID: 39316078Meta-Analysis
Incidence and influencing factors of tooth discoloration in children using doxycycline: a meta-analysis.
Ma Kun, Lu Mingjing, Li Hao et al. · Front Pediatr · 2025
PMID: 40918671Meta-AnalysisFull text (PMC)
Pharmacokinetic-Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing.
Toutain Pierre-Louis, Bousquet-Melou Alain, Ferran Aude A et al. · J Vet Pharmacol Ther · 2025
PMID: 40247665Meta-AnalysisFull text (PMC)
Efficacy and safety of doxycycline for severe Mycoplasma pneumoniae pneumonia in pediatric patients.
Zhao Qian, Sang Xu, Gao Ding et al. · Clin Exp Med · 2025
PMID: 40694196Meta-AnalysisFull text (PMC)
Dental safety of short-term doxycycline use in children under 8 years: a systematic review and meta-analysis.
Rajan Anusiga Sigamani, Gopal Muthu, Periyathambi Madhumidha et al. · Front Pharmacol · 2025
PMID: 41069592Meta-AnalysisFull text (PMC)
Efficacy of postexposure prophylaxis with doxycycline (Doxy-PEP) in reducing sexually transmitted infections: a systematic review and meta-analysis.
Sokoll Paulo Roberto, Migliavaca Celina Borges, Döring Stephan et al. · Sex Transm Infect · 2025
PMID: 39097410Meta-Analysis
In vitro antimicrobial activity of doxycycline, minocycline, and tigecycline against Mycobacterium abscessus complex: A meta-analysis study.
Zhang Weihe, Dong Lingling, Men Peixuan et al. · Diagn Microbiol Infect Dis · 2024
PMID: 39032320Meta-Analysis
Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania.
Mwengee William, Butler Thomas, Mgema Samuel et al. · Clin Infect Dis · 2006
PMID: 16447105RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Doxycycline (substance)
SNOMED CT
372478003
UMLS CUI
C0013090
RxNorm CUI
3640
Labeler
Physicians Total Care, Inc.

Clinical Data

This intervention maps to 12 entities in the Ltrl knowledge graph.

12
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
22
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.