Substance / Medication

Ephedrine hydrochloride

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Orthostatic hypotension

Rhinitis

Airway hyperreactivity

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Leukocytes

LOINC 26464-8

secondary

Eosinophils

LOINC 711-2

primary

IgE

LOINC 19113-0

primary

Clinical Trials

359 trials linked to this intervention

359

Total Trials

Recruiting

119

With Results

Recent Trials

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

NCT00001406Recruiting800 enrolled

Role of Genetic Factors in the Development of Lung Disease

NCT00001532Recruiting3500 enrolled

Sample Collections From the Airways of Asthmatic Patients

NCT00001888Completed574 enrolled

A Study for Patients With Neurogenic Orthostatic Hypotension

NCT00046475Phase 4Completed140 enrolled

Nasonex Compared With Placebo in Participants With Seasonal Allergic Rhinitis (SAR) and Concomitant Asthma (P03280)

NCT00070707Phase 4Completed188 enrolled

View all 359 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

A systematic review of phenytoin intoxication induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets in China.

Zhang Lingxia, Li Zhenfei, Ma Gaiying et al. · Medicine (Baltimore) · 2018

PMID: 30572493Meta-AnalysisFull text (PMC)

Onset of action of fexofenadine hydrochloride 60 mg/pseudoephedrine hydrochloride 120 mg in subjects aged 12 years with moderate to severe seasonal allergic rhinitis: a pooled analysis of two single-dose, randomized, double-blind, placebo-controlled allergen exposure unit studies.

Berkowitz Robert B, McCafferty Frank, Lutz Cheryl et al. · Clin Ther · 2006

PMID: 17157121RCT

[A prospective multicenter randomized controlled clinical study on the efficacy and safety of Guaifenesin compound pseudoephedrine hydrochloride oral solution].

[object Object], Lu Quan · Zhonghua Er Ke Za Zhi · 2010

PMID: 20426957Observational

Safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for adjunctive symptom relief of acute respiratory infections.

Kikano George · Postgrad Med · 2009

PMID: 19491556Observational

A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections.

LaForce Craig, Gentile Deborah A, Skoner David P · Postgrad Med · 2008

PMID: 18654069Observational

High-performance liquid chromatographic method development and validation for the simultaneous quantitation of naproxen sodium and pseudoephedrine hydrochloride impurities.

Ekpe A, Tong J H, Rodriguez L · J Chromatogr Sci · 2001

PMID: 11277256Observational

[A case of fixed drug eruption due to ephedrine hydrochloride].

Tanimoto K, Shimakage T, Ayabe Y et al. · Masui · 2000

PMID: 11193515Case Report

Type I Hypersensitivity Reactions Induced by dl-Methylephedrine Hydrochloride.

Fujii Noriyoshi, Furuta Junichi, Kubota Noriko et al. · Int J Dermatol · 2026

PMID: 40836395Other

Green Easily Implemented Spectrophotometric Methods for Concurrent Determination of Ephedrine Hydrochloride and Naphazoline Nitrate in Nasal Preparations Containing Methylparaben.

Abdelfatah Rehab M, Magdy Maimana A · J AOAC Int · 2023

PMID: 37140554Other

Stability of (1R,2S)-(-)-Ephedrine hydrochloride in-inoculated urine and blood samples.

Khaled Jamal M, Alharbi Naiyf S, Al-Huwaymil Rayan M et al. · Saudi J Biol Sci · 2023

PMID: 37266409OtherFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Allergy & Immunology (Internal Medicine) Physician

Internal Medicine — Allergy & Immunology

NUCC 207RA0201X

Pulmonary Disease Physician

Internal Medicine — Pulmonary Disease

NUCC 207RP1001X

Find a Provider

Health Goals

Goals connected through associated conditions

Support Respiratory Health

Quick Facts

Type: Substance / Medication
Fully Specified Name: Ephedrine hydrochloride (substance)
SNOMED CT: 387327006
UMLS CUI: C0304425

Clinical Data

This intervention maps to 9 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

359

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.