Substance / Medication

Estradiol benzoate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Hypogonadism

Primary ovarian failure

Neoplasm of prostate

Neoplasm of breast

Menopausal flushing

Premature ovarian failure

Climacteric flushing

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Thyrotropin

LOINC 3016-3

secondary

Estradiol

LOINC 2243-4

primary

Testosterone

LOINC 2986-8

primary

Clinical Trials

78 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

TRADE-Testosterone Replacement and Dutasteride Effectiveness

NCT00194675Phase 4Completed53 enrolled

Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function

NCT00195520Phase 4Completed100 enrolled

Efficacy and Safety Study in Postmenopausal Women to Determine the Lowest Effective Dose for Relief of Moderate to Severe Hot-Flushes

NCT00206622Phase 4Completed425 enrolled

Study of Paxil Use in Menopausal Women

NCT00225914Phase 4Completed64 enrolled

Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia

NCT00227942Phase 4Completed86 enrolled

View all 78 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Incorporation of estradiol benzoate to CIDR protocol improves the reproductive responses in crossbred dairy heifers.

Mehmood Muhammad Usman, Qamar Ahmad, Sattar Abdul et al. · Trop Anim Health Prod · 2017

PMID: 27913974RCT

Ovulation synchronization with estradiol benzoate or GnRH in a timed artificial insemination protocol in buffalo cows and heifers during the nonbreeding season.

Carvalho N A T, Soares J G, Souza D C et al. · Theriogenology · 2017

PMID: 27743689RCT

Progesterone-based fixed-time artificial insemination protocols for dairy cows: Gonadotropin-releasing hormone versus estradiol benzoate at initiation and estradiol cypionate versus estradiol benzoate at the end.

Melo L F, Monteiro P L J, Surjus R S et al. · J Dairy Sci · 2016

PMID: 27568044RCT

Hormone supplementation protocol using estradiol benzoate and long-acting progesterone is efficient in maintaining pregnancy of anovulatory recipient mares during autumn transitional phase.

Botelho Jorge H V, Pessoa Gabriela O, Rocha Luiz G P et al. · Anim Reprod Sci · 2015

PMID: 25578506RCT

Administration of estradiol benzoate before insemination could skew secondary sex ratio toward males in Holstein dairy cows.

Emadi S R, Rezaei A, Bolourchi M et al. · Domest Anim Endocrinol · 2014

PMID: 24906936RCT

Ovarian dynamics in response to two modified intravaginal progesterone releasing device and oestradiol benzoate based ovulation synchronisation protocols designed for use in Brahman heifers.

Edwards S A A, Atkinson P C, Satake N et al. · Anim Reprod Sci · 2014

PMID: 24880980RCT

Effects of estradiol benzoate and trenbolone acetate, alone or in combination at dose levels present in Synovex Choice, on performance by feedlot heifers.

Cleale R M, Amodie D, Bechtol D T et al. · J Anim Sci · 2013

PMID: 23307845RCT

Evaluation of the hypothalamus-pituitary axis response to exogenous GnRH, estradiol benzoate, and LH during the postpartum period in Nellore cows.

Pinheiro Vinícius G, Cury José Renato L M, Satrapa Rafael A et al. · Theriogenology · 2013

PMID: 23321276RCT

Influence of the length of progestagen treatment and the time of oestradiol benzoate application on the ovulatory follicle size and ovulation time in anoestrous and cyclic beef cows.

Manes J, Aller J F, Callejas S S et al. · Reprod Domest Anim · 2012

PMID: 21883518RCT

Comparison of progesterone-based protocols with gonadotropin-releasing hormone or estradiol benzoate for timed artificial insemination or embryo transfer in lactating dairy cows.

Vasconcelos J L M, Jardina D T G, Sá Filho O G et al. · Theriogenology · 2011

PMID: 21247621RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Endocrinology, Diabetes & Metabolism Physician

Internal Medicine — Endocrinology, Diabetes & Metabolism

Urology

Health Goals

Goals connected through associated conditions

Balance Hormones

Quick Facts

Type: Substance / Medication
Fully Specified Name: Estradiol benzoate (substance)
SNOMED CT: 96349008
UMLS CUI: C0167626

Clinical Data

This intervention maps to 13 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.