Substance / Medication

Ferrous fumarate

Overview

Active Ingredient

ferrous fumarate

RxNorm CUI

24941

Indications

To provide vitamin and mineral supplementation prior to and through pregnancy and during the postnatal period, for both lactating and non-lactating mothers.

Labeler: Pharmics, Inc.Updated: 2012-09-06T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of the reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Iron deficiency anemia

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Iron binding capacity

LOINC 2500-7

secondary

Hemoglobin

LOINC 718-7

primary

Iron

LOINC 2498-4

primary

Research Evidence

Published studies and systematic reviews

Sort:

Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.

Milman Nils Thorm, Bergholt Thomas · J Pregnancy · 2024

PMID: 39582678RCTFull text (PMC)

A randomized controlled trial of thrice-weekly versus thrice-daily oral ferrous fumarate treatment in adult patients with iron-deficiency anemia.

Jongkraijakra Siddhibhong, Doungngern Thitima, Sripakdee Warunsuda et al. · Ann Hematol · 2023

PMID: 37010569RCTFull text (PMC)

Ferric Carboxymaltose Versus Ferrous Fumarate in Anemic Children with Inflammatory Bowel Disease: The POPEYE Randomized Controlled Clinical Trial.

Bevers Nanja, Van de Vijver Els, Aliu Arta et al. · J Pediatr · 2023

PMID: 36563900RCT

Kinetics of iron absorption from ferrous fumarate with and without galacto-oligosaccharides determined from stable isotope appearance curves in women.

Husmann Frederike M D, Stierli Laura, Bräm Dominic S et al. · Am J Clin Nutr · 2022

PMID: 34726703RCTFull text (PMC)

Prebiotic Galacto-Oligosaccharides and Fructo-Oligosaccharides, but Not Acacia Gum, Increase Iron Absorption from a Single High-Dose Ferrous Fumarate Supplement in Iron-Depleted Women.

Giorgetti Ambra, Husmann Frederike M D, Zeder Christophe et al. · J Nutr · 2022

PMID: 35015879RCT

Polyphenol-rich tea decreases iron absorption from fortified wheat bread in Senegalese mother-child pairs and bioavailability of ferrous fumarate is sharply lower in children.

Ndiaye Ndèye Fatou, Idohou-Dossou Nicole, Bürkli Simone et al. · Eur J Clin Nutr · 2020

PMID: 32203231RCT

Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women.

Jeroense Frederike M D, Michel Ladina, Zeder Christophe et al. · J Nutr · 2019

PMID: 31004135RCT

Iron Fortified Complementary Foods Containing a Mixture of Sodium Iron EDTA with Either Ferrous Fumarate or Ferric Pyrophosphate Reduce Iron Deficiency Anemia in 12- to 36-Month-Old Children in a Malaria Endemic Setting: A Secondary Analysis of a Cluster-Randomized Controlled Trial.

Glinz Dominik, Wegmüller Rita, Ouattara Mamadou et al. · Nutrients · 2017

PMID: 28708072RCTFull text (PMC)

Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy. A randomized controlled trial.

Bhavi Shruti B, Jaju Purushottam B · BMC Pregnancy Childbirth · 2017

PMID: 28482869RCTFull text (PMC)

Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children.

Teshome Emily M, Andang'o Pauline E A, Osoti Victor et al. · BMC Med · 2017

PMID: 28449690RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Internal Medicine Physician

Internal Medicine

NUCC 207R00000X

Hematology (Internal Medicine) Physician

Internal Medicine — Hematology

NUCC 207RH0000X

Find a Provider

Health Goals

Goals connected through associated conditions

Optimize Iron and Blood Health Optimize Nutrient Levels

Quick Facts

Type: Substance / Medication
Fully Specified Name: Ferrous fumarate (substance)
SNOMED CT: 387289009
UMLS CUI: C0060276
RxNorm CUI: 24941
Labeler: Pharmics, Inc.

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.