Substance / Medication

Ferrous gluconate

SNOMED 387147005 UMLS C0060277

Overview

Active Ingredient

ferrous gluconate

RxNorm CUI

24942

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Iron deficiency anemia

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Iron binding capacity

LOINC 2500-7

secondary

Hemoglobin

LOINC 718-7

primary

Iron

LOINC 2498-4

primary

Clinical Trials

4 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Iron Prehabilitation in Endometrial Cancer

NCT06049693Phase 4Completed156 enrolled

Lactoferrin With Ferrous Gluconate Versus Ferrous Gluconate in Treatment of Iron Deficiency Anemia During Pregnancy

NCT06252103Phase 4Completed40 enrolled

Iron Absorption Trial

NCT02228902Phase 4Completed24 enrolled

Optimizing Iron Suppletion After Roux-en-Y Gastric Bypass

NCT02271997Phase 4Completed120 enrolled

View all 4 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Alginate inhibits iron absorption from ferrous gluconate in a randomized controlled trial and reduces iron uptake into Caco-2 cells.

Wawer Anna A, Harvey Linda J, Dainty Jack R et al. · PLoS One · 2014

PMID: 25391138RCTFull text (PMC)

Ferrous gluconate and ferrous sulfate added to a complementary food distributed by the Mexican nutrition program Oportunidades have a comparable efficacy to reduce iron deficiency in toddlers.

Shamah-Levy Teresa, Villalpando Salvador, Rivera-Dommarco Juan A et al. · J Pediatr Gastroenterol Nutr · 2008

PMID: 18979587RCT

Fortifying milk with ferrous gluconate and zinc oxide in a public nutrition program reduced the prevalence of anemia in toddlers.

Villalpando Salvador, Shamah Teresa, Rivera Juan A et al. · J Nutr · 2006

PMID: 16988138RCT

Iron polymaltose versus ferrous gluconate in the prevention of iron deficiency anemia of infancy.

Jaber Lutfi, Rigler Shmuel, Taya Ahmad et al. · J Pediatr Hematol Oncol · 2010

PMID: 20930652Observational

Compensating for iron loss in regular blood donors using ferrous gluconate and ascorbic acid.

Radtke Hartmut, Tegtmeier Joanna, Röcker Lothar et al. · Transfusion · 2005

PMID: 15987376Observational

Thrombocytopenia following iron repletion with ferrous gluconate.

Al Saud Aljoharah A, AlRomaizan Muneerah R, Alkhunizan Muath A · Saudi Med J · 2024

PMID: 39074892Case ReportFull text (PMC)

Ferrous gluconate-loaded sodium alginate hydrogel facilitates ferroptosis in Streptococcus hemolyticus and cures Streptococcal infections.

Yao Lishan, Xiang Fukun, Peng Shurui et al. · Int J Biol Macromol · 2025

PMID: 40651645Other

Ferrous gluconate triggers ferroptosis in Escherichia coli: Implications of lipid peroxidation and DNA damage.

Jing Wenhui, Guo Rongxian, Zhu Xiaolin et al. · Microbiol Res · 2024

PMID: 38636240Other

The effect of iron absorption in ferrous gluconate form from enriched rice flour using andigestion model and a Caco-2 cell model.

Lin Jing, Liu Caiyu, Bai Ru et al. · Food Funct · 2024

PMID: 39109657Other

High internal phase Pickering emulsions co-loaded with astaxanthin and ferrous gluconate improve iron deficiency anemia in mice and their applications in 3D printing.

Zheng Jingyi, Xiong Wenyun, Yi Junjie et al. · Food Res Int · 2024

PMID: 39593324Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Internal Medicine Physician

Internal Medicine

NUCC 207R00000X

Hematology (Internal Medicine) Physician

Internal Medicine — Hematology

NUCC 207RH0000X

Find a Provider

Health Goals

Goals connected through associated conditions

Optimize Iron and Blood Health Optimize Nutrient Levels

Quick Facts

Type: Substance / Medication
Fully Specified Name: Ferrous gluconate (substance)
SNOMED CT: 387147005
UMLS CUI: C0060277
RxNorm CUI: 24942

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.