Substance / Medication

Ferrous sulphate

SNOMED 387402000 UMLS C0060282

Overview

Active Ingredient

ferrous sulfate

RxNorm CUI

24947

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Iron deficiency anemia

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Iron binding capacity

LOINC 2500-7

secondary

Hemoglobin

LOINC 718-7

primary

Iron

LOINC 2498-4

primary

Clinical Trials

18 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Early Antenatal Support for Iron Deficiency Anemia

NCT04278651Phase 4Recruiting80 enrolled

Oral Iron in Children With Chronic Kidney Disease

NCT03991169Phase 4Recruiting40 enrolled

IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches

NCT07053475Phase 4Recruiting250 enrolled

Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial

NCT03438227Phase 4Completed38 enrolled

Potential Harms of Untargeted Iron Supplementation in Cambodia Where Iron Deficiency is Not the Cause of Anemia

NCT04017598Phase 4Completed480 enrolled

View all 18 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.

Milman Nils Thorm, Bergholt Thomas · J Pregnancy · 2024

PMID: 39582678RCTFull text (PMC)

Safety and efficacy of iron supplementation with 3 months of daily ferrous sulphate in children living with HIV and mild-to-moderate anaemia in Uganda: a double-blind, randomised, placebo-controlled trial.

Frosch Anne E P, Musiime Victor, Staley Christopher et al. · Lancet HIV · 2024

PMID: 39401504RCTFull text (PMC)

Tolerability of Oral Supplementation with Microencapsulated Ferric Saccharate Compared to Ferrous Sulphate in Healthy Premenopausal Woman: A Crossover, Randomized, Double-Blind Clinical Trial.

Friling Marina, García-Muñoz Ana María, Perrinjaquet-Moccetti Tania et al. · Int J Mol Sci · 2022

PMID: 36293136RCTFull text (PMC)

Oral Ferrous Sulphate Improves Functional Capacity on Heart Failure Patients with Iron Deficiency Anemia.

Suryani Lita Dwi, Raharjo Sunu Budhi, Sagita Rima et al. · Glob Heart · 2022

PMID: 36578916RCTFull text (PMC)

Comparison of efficacy & safety of iron polymaltose complex & ferrous ascorbate with ferrous sulphate in pregnant women with iron-deficiency anaemia.

Chavan Suyash, Rana Proteesh, Tripathi Reva et al. · Indian J Med Res · 2021

PMID: 34782532RCTFull text (PMC)

Acute Administration of Bioavailable Curcumin Alongside Ferrous Sulphate Supplements Does Not Impair Iron Absorption in Healthy Adults in a Randomised Trial.

Lorinczova Helena Tiekou, Begum Gulshanara, Renshaw Derek et al. · Nutrients · 2021

PMID: 34371810RCTFull text (PMC)

Daily versus twice daily dose of ferrous sulphate supplementation in pregnant women: A randomized clinical trial.

Adaji J A, Isah A Y, Agida E T et al. · Niger J Clin Pract · 2019

PMID: 31417058RCT

A Prospective Randomised Controlled Trial of a Single Intravenous Infusion of Ferric Carboxymaltose vs Single Intravenous Iron Polymaltose or Daily Oral Ferrous Sulphate in the Treatment of Iron Deficiency Anaemia in Pregnancy.

Khalafallah Alhossain A, Hyppa Annemarie, Chuang Anthony et al. · Semin Hematol · 2018

PMID: 30502851RCT

A rapid, simple questionnaire to assess gastrointestinal symptoms after oral ferrous sulphate supplementation.

Pereira Dora I A, Couto Irving Susana S, Lomer Miranda C E et al. · BMC Gastroenterol · 2014

PMID: 24899360RCTFull text (PMC)

[Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants].

Amaral Diego, Galimberti Griselda, Cuesta Soledad et al. · Rev Fac Cien Med Univ Nac Cordoba · 2012

PMID: 23286539RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Internal Medicine Physician

Internal Medicine

NUCC 207R00000X

Hematology (Internal Medicine) Physician

Internal Medicine — Hematology

NUCC 207RH0000X

Find a Provider

Health Goals

Goals connected through associated conditions

Optimize Iron and Blood Health Optimize Nutrient Levels

Quick Facts

Type: Substance / Medication
Fully Specified Name: Ferrous sulfate (substance)
SNOMED CT: 387402000
UMLS CUI: C0060282
RxNorm CUI: 24947

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.