Substance / Medication

Ferumoxytol

Overview

Active Ingredient
ferumoxytol
RxNorm CUI
473387

Indications

FERABRIGHT is indicated for magnetic resonance imaging (MRI) of the brain in adults with known or suspected malignant neoplasms in the brain to visualize lesions with a disrupted blood-brain barrier.

Labeler: Azurity Pharmaceuticals, Inc.Updated: 2025-10-14T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Fatal and serious hypersensitivity reactions, including anaphylaxis, have occurred in patients receiving ferumoxytol products that contain the same active ingredient as FERABRIGHT. Initial signs may include hypotension, syncope, unresponsiveness, and cardiac/cardiorespiratory arrest. Hypersensitivit

Contraindications

When this intervention should not be used

5.1 [see Warnings and Precautions ()] FERABRIGHT is contraindicated in patients with known hypersensitivity to ferumoxytol, any of FERABRIGHT’s components, or any other intravenous iron products. Reactions have included anaphylaxis.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
The Efficacy of Ferumoxytol for Iron Deficiency Anemia: A Meta-Analysis of Randomized Controlled Trials.
Shao Yanping, Luo Wenda, Xu Haiyan et al. · Acta Haematol · 2019
PMID: 31434073Meta-Analysis
The safety and efficacy of ferumoxytol in the treatment of iron deficiency: a systematic review and meta-analysis.
Abdulrehman Jameel, Tang Grace H, Auerbach Michael et al. · Transfusion · 2019
PMID: 31762068Meta-Analysis
Population pharmacokinetic meta-analysis to bridge ferumoxytol plasma pharmacokinetics across populations.
Plock Nele, Facius Axel, Lahu Gezim et al. · Clin Pharmacokinet · 2015
PMID: 25370033Meta-AnalysisFull text (PMC)
Neonatal outcomes from a randomized controlled trial of maternal treatment of iron deficiency anemia with intravenous ferumoxytol vs oral ferrous sulfate.
Awomolo Adeola M, McWhirter Amanda, Sadler Lynn C et al. · Am J Obstet Gynecol MFM · 2023
PMID: 37348817RCT
Intravenous infusions of ferumoxytol compared to oral ferrous sulfate for the treatment of anemia in pregnancy: a randomized controlled trial.
Awomolo Adeola M, McWhirter Amanda, Sadler Lynn C et al. · Am J Obstet Gynecol MFM · 2023
PMID: 37348816RCT
Pharmacokinetics of Ferumoxytol in the Abdomen and Pelvis: A Dosing Study with 1.5- and 3.0-T MRI Relaxometry.
Wells Shane A, Schubert Tilman, Motosugi Utaroh et al. · Radiology · 2020
PMID: 31714191RCT
Iron indices and intravenous ferumoxytol: time to steady-state.
Kapoian Toros, O'Mara Neeta Bahal, Carreon Myra et al. · Ann Pharmacother · 2012
PMID: 22968523RCT
FDA report: Ferumoxytol for intravenous iron therapy in adult patients with chronic kidney disease.
Lu Min, Cohen Martin H, Rieves Dwaine et al. · Am J Hematol · 2010
PMID: 20201089RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ferumoxytol (substance)
SNOMED CT
442951001
UMLS CUI
C0060274
RxNorm CUI
473387
Labeler
Azurity Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

1
Conditions
3
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.