Substance / Medication

Fludrocortisone

Overview

Active Ingredient
fludrocortisone
RxNorm CUI
4452

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Effect of hydrocortisone-fludrocortisone combination on mortality in septic shock: a systematic review and meta-analysis.
Wu Jheng-Yen, Liu Mei-Yuan, Liu Ting-Hui et al. · Infection · 2025
PMID: 39192056Meta-Analysis
Corticosteroids for sepsis and septic shock: a meta-analysis of 18 RCTs with dose-stratified and fludrocortisone subgroup evaluation.
Ruyuan Lv, Zhangshun Shen, Hongling Li et al. · BMC Anesthesiol · 2025
PMID: 41120996Meta-AnalysisFull text (PMC)
Fludrocortisone for orthostatic hypotension.
Veazie Stephanie, Peterson Kim, Ansari Yasmin et al. · Cochrane Database Syst Rev · 2021
PMID: 34000076Meta-AnalysisFull text (PMC)
Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension: CONFORM-OH pilot RCT and economic evaluation.
Mossop Helen, Al Ashmori Sarah, Sotire Tumi et al. · Health Technol Assess · 2025
PMID: 41217271RCTFull text (PMC)
Fludrocortisone dose-response relationship in septic shock: a randomised phase II trial.
Walsham James, Hammond Naomi, Blumenthal Antje et al. · Intensive Care Med · 2024
PMID: 39235623RCTFull text (PMC)
Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial.
Heming Nicholas, Renault Alain, Kuperminc Emmanuelle et al. · Lancet Respir Med · 2024
PMID: 38310918RCT
Effect of Fludrocortisone on Intradialytic Hypotension: An Open-Label, Randomized, Crossover Study.
Vongchaiudomchoke Thanawat, Siriyong Patchanon, Wachiraphansakul Nuttaya et al. · Blood Purif · 2023
PMID: 36473430RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Fludrocortisone (substance)
SNOMED CT
116586002
UMLS CUI
C0016280
RxNorm CUI
4452

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.