Substance / Medication

Folinic acid

Overview

Active Ingredient
leucovorin
RxNorm CUI
6313

Indications

® EnBrace HR 12 12 is indicated in the TREATMENT of vitamin deficiency - specifically vitamin Bdeficiency, and the PREVENTION of vitamin B-cofactor deficiency, l-methylfolate. 9 12 Requirements of vitamin Band/or vitamin Bin excess of normal due to pregnancy can usually be met with oral supplementation.

Labeler: Jaymac Pharmaceuticals, LLCUpdated: 2026-02-10T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea Beverley, Swinden Michael V, Ghogomu Elizabeth Tanjong et al. · J Rheumatol · 2014
PMID: 24737913Meta-Analysis
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Shea Beverley, Swinden Michael V, Tanjong Ghogomu Elizabeth et al. · Cochrane Database Syst Rev · 2013
PMID: 23728635Meta-AnalysisFull text (PMC)
Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials.
Neoptolemos J P, Stocken D D, Tudur Smith C et al. · Br J Cancer · 2009
PMID: 19127260Meta-AnalysisFull text (PMC)
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Ortiz Z, Shea B, Suarez Almazor M et al. · Cochrane Database Syst Rev · 2000
PMID: 10796393Meta-Analysis
Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women: A Randomized, Controlled Trial.
Bumrungpert Akkarach, Pavadhgul Patcharanee, Piromsawasdi Theera et al. · Nutrients · 2022
PMID: 35276810RCTFull text (PMC)
Folinic Acid as Adjunctive Therapy in Treatment of Inappropriate Speech in Children with Autism: A Double-Blind and Placebo-Controlled Randomized Trial.
Batebi Neda, Moghaddam Hossein Sanjari, Hasanzadeh Alireza et al. · Child Psychiatry Hum Dev · 2021
PMID: 33029705RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Folinic acid (substance)
SNOMED CT
396065004
UMLS CUI
C0023413
RxNorm CUI
6313
Labeler
Jaymac Pharmaceuticals, LLC

Clinical Data

This intervention maps to 3 entities in the Ltrl knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.