Substance / Medication

Histrelin acetate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Precocious puberty

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

Clinical characteristics and treatment patterns with histrelin acetate subcutaneous implants vs. leuprolide injections in children with precocious puberty: a real-world study using a US claims database.

Silverman Lawrence A, Han Xu, Huang Huan et al. · J Pediatr Endocrinol Metab · 2021

PMID: 34147047Observational

A review of the pharmacokinetic and pharmacological properties of a once-yearly administered histrelin acetate implant in the treatment of prostate cancer.

Schlegel Peter · BJU Int · 2009

PMID: 19228147Review

A review of the use of histrelin acetate in the treatment of prostate cancer.

Crawford E David · BJU Int · 2009

PMID: 19228148Review

Fertility preservation in transfeminine adolescents using TESE at the time of Histrelin Acetate subcutaneous implant placement: A Case Series.

Barrera Ellis, Locks Rachel, Kremen Jessica et al. · J Pediatr Urol · 2023

PMID: 37770134Other

Long-term efficacy and tolerability of abdominal once-yearly histrelin acetate subcutaneous implants in patients with advanced prostate cancer.

Woolen Sean, Holzmeyer Cameron, Nesbitt Emily et al. · Prostate Cancer · 2014

PMID: 25548680OtherFull text (PMC)

Comparative Efficacy of Histrelin Acetate and hCG for Inducing Ovulation in Brazilian Northeastern Jennies (Equus africanus asinus).

Oliveira Sidnei N, Segabinazzi Lorenzo G T M, Canuto Lucas et al. · J Equine Vet Sci · 2020

PMID: 32797776Preclinical

Histrelin acetate-induced ovulation in Brazilian Northeastern jennies (Equus asinus) with different follicle diameters.

de Oliveira Sidnei Nunes, Canuto Lucas, Segabinazzi Lorenzo Garrido Teixeira M et al. · Theriogenology · 2019

PMID: 31254727Preclinical

Long-term efficacy and tolerability of once-yearly histrelin acetate subcutaneous implant in patients with advanced prostate cancer.

Shore Neal, Cookson Michael S, Gittelman Marc C · BJU Int · 2012

PMID: 21851539Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Histrelin acetate (substance)
SNOMED CT: 109050002
UMLS CUI: C0724597

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.