Substance / Medication

Human fibrinogen

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Afibrinogenaemia

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

A Randomized Pilot Trial Assessing the Role of Human Fibrinogen Concentrate in Decreasing Cryoprecipitate Use and Blood Loss in Infants Undergoing Cardiopulmonary Bypass.

Tirotta Christopher F, Lagueruela Richard G, Gupta Apeksha et al. · Pediatr Cardiol · 2022

PMID: 35305111RCTFull text (PMC)

[Indication and technique of human fibrinogen/thrombin-coated collagen patch use in mucogingival surgery].

Zorina O A, Molchanov A M, Balykin R A · Stomatologiia (Mosk) · 2014

PMID: 25377582RCT

Comparison of the efficacy of two human fibrinogen concentrates to treat dilutional coagulopathy in vitro.

Haas Thorsten, Cushing Melissa M, Asmis Lars M · Scand J Clin Lab Invest · 2018

PMID: 29446989Observational

Evaluation of the efficiency under current use of human fibrinogen concentrate in trauma patients with life-threatening hemorrhagic disorders.

González-Guerrero Celia, Lozano-Andreu Toni, Roch-Santed Maria et al. · Blood Coagul Fibrinolysis · 2017

PMID: 27254440Observational

Efficacy of Human Fibrinogen-Thrombin Patch (TachoSil) Clinical Application in Upper Gastrointestinal Cancer Surgery.

Marano Luigi, Di Martino Natale · J Invest Surg · 2016

PMID: 27191688Observational

Transfusion and hematologic variables after fibrinogen or platelet transfusion in valve replacement surgery: preliminary data of purified lyophilized human fibrinogen concentrate versus conventional transfusion.

Tanaka Kenichi A, Egan Katherine, Szlam Fania et al. · Transfusion · 2014

PMID: 23718572Observational

Efficacy and safety of human fibrinogen-thrombin patch (TachoSil®) in the treatment of postoperative air leakage in patients submitted to redo surgery for lung malignancies: a randomized trial.

Filosso Pier Luigi, Ruffini Enrico, Sandri Alberto et al. · Interact Cardiovasc Thorac Surg · 2013

PMID: 23420053ObservationalFull text (PMC)

Comparable effect of recombinant and plasma-derived human fibrinogen concentrate on ex vivo clot formation after cardiac surgery.

Radulovic V, Baghaei F, Blixter I Fagerberg et al. · J Thromb Haemost · 2012

PMID: 22712790Observational

Evaluation of the ability of Streptococcus agalactiae strains isolated from genital and neonatal specimens to bind to human fibrinogen and correlation with characteristics of the fbsA and fbsB genes.

Rosenau Agnès, Martins Karine, Amor Souheila et al. · Infect Immun · 2007

PMID: 17158903ObservationalFull text (PMC)

Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency.

Kreuz Wolfhart, Meili Esther, Peter-Salonen Kristiina et al. · Transfus Apher Sci · 2005

PMID: 15919240Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Human fibrinogen (substance)
SNOMED CT: 418326009
UMLS CUI: C2587184

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.