Substance / Medication

Hydrocortisone

Overview

Active Ingredient
hydrocortisone
RxNorm CUI
5492

Indications

Hydrocortisone tablets are indicated in the following conditions.

Labeler: PD-Rx Pharmaceuticals, Inc.Updated: 2026-02-25T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Systemic fungal infections and known hypersensitivity to components

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

51 trials linked to this intervention

51
Total Trials
18
Recruiting
9
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Timing of hydrocortisone therapy in neonates with shock: a systematic review, meta-analysis, and clinical practice guideline.
Ramaswamy Viraraghavan Vadakkencherry, Kumar Gunjana, Pullattayil S Abdul Kareem et al. · Front Pediatr · 2025
PMID: 40144277Meta-AnalysisFull text (PMC)
[Meta-analysis of hydrocortisone in the treatment of severe community-acquired pneumonia].
Gu Xue, Yang Penglei, Yu Lina et al. · Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · 2025
PMID: 40820529Meta-Analysis
Effect of hydrocortisone-fludrocortisone combination on mortality in septic shock: a systematic review and meta-analysis.
Wu Jheng-Yen, Liu Mei-Yuan, Liu Ting-Hui et al. · Infection · 2025
PMID: 39192056Meta-Analysis
Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review.
Alekrish Yazeed, Alotaibi Mohammed, Ekhzaimy Aishah · Rev Endocr Metab Disord · 2024
PMID: 39218827Meta-Analysis
Hydrocortisone in very preterm neonates for BPD prevention: meta-analysis and effect size modifiers.
De Luca Daniele, Ferraioli Sara, Watterberg Kristi L et al. · Arch Dis Child Fetal Neonatal Ed · 2024
PMID: 38237961Meta-Analysis
Early use of low-dose hydrocortisone can reduce in-hospital mortality in patients with septic shock: A systematic review and meta-analysis.
Song Binglin, Zheng Xiangde, Fu Kangrui et al. · Medicine (Baltimore) · 2024
PMID: 39612454Meta-AnalysisFull text (PMC)
1% hydrocortisone ointment is an effective treatment of pruritus ani: a pilot randomized controlled crossover trial.
Al-Ghnaniem R, Short K, Pullen A et al. · Int J Colorectal Dis · 2007
PMID: 17534634RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Hydrocortisone (substance)
SNOMED CT
396458002
UMLS CUI
C0020268
RxNorm CUI
5492
Labeler
PD-Rx Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 21 entities in the Ltrl knowledge graph.

11
Conditions
4
Biomarkers
4
Specialists
0
Symptoms
51
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.