Substance / Medication

Ibuprofen

Overview

Active Ingredient
ibuprofen
RxNorm CUI
5640

Indications

WARNINGS Carefully consider the potential benefits and risks of Ibuprofentablets and other treatment options before deciding to use Ibuprofen.Use the lowest effective dose for the shortest duration consistent withindividual patient treatment goals (see). Ibuprofen tablets are indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Ibuprofen tablets are indicated for relief of mild to moderate pain. Ibuprofen tablets are also indicated for the treatment of prima

Labeler: Aphena Pharma Solutions - Tennessee, LLCUpdated: 2026-02-20T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Cardiovascular Thrombotic Events Gastrointestinal Risk WARNINGS PRECAUTIONS Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and ma

Contraindications

When this intervention should not be used

Ibuprofen tablets are contraindicated in patients with known hypersensitivityto ibuprofen. WARNINGS, Anaphylactoid Reactions, and PRECAUTIONS, Preexisting Asthma ). Ibuprofen tablets should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspir

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

139 trials linked to this intervention

139
Total Trials
22
Recruiting
45
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Is ibuprofen associated with upper gastrointestinal bleeding? A systematic review and meta-analysis.
Gkiouras Konstantinos, Myrogiannis Ioannis, Kouvelas Dimitrios · Inflammopharmacology · 2025
PMID: 40728676Meta-Analysis
Short-term Dual Therapy or Mono Therapy With Acetaminophen and Ibuprofen for Fever: A Network Meta-Analysis.
De la Cruz-Mena Juan E, Veroniki Areti-Angeliki, Acosta-Reyes Jorge et al. · Pediatrics · 2024
PMID: 39318339Meta-Analysis
Ibuprofen for acute postoperative pain in children.
Pessano Sara, Gloeck Natasha R, Tancredi Luca et al. · Cochrane Database Syst Rev · 2024
PMID: 38180091Meta-AnalysisFull text (PMC)
Efficacy and safety of perioperative ibuprofen for pain control after pediatric tonsillectomy: A systemic review and meta-analysis.
Kim Do Hyun, Stybayeva Gulnaz, Hwang Se Hwan · Int J Pediatr Otorhinolaryngol · 2024
PMID: 39178604Meta-Analysis
Therapeutic Efficacy and Safety of Paracetamol versus Ibuprofen in Patent Ductus Arteriosus in Newborns: A Systematic Review.
da Silva Halecy Davidson Sousa, Franco Eryvelton de Souza, Lima Larissa Caroline de Almeida Sousa et al. · Arq Bras Cardiol · 2024
PMID: 39661802Meta-AnalysisFull text (PMC)
Ibuprofen efficacy, tolerability and safety in obese children: a systematic review.
Shamsaee Eman, Huws Alaw, Gill Andrea et al. · Arch Dis Child · 2023
PMID: 36385006Meta-Analysis
Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis.
Alnasser Ammar, Alhumrran Hassan, Alfehaid Mustafa et al. · Sci Rep · 2023
PMID: 38057585Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ibuprofen (substance)
SNOMED CT
387207008
UMLS CUI
C0020740
RxNorm CUI
5640
Labeler
Aphena Pharma Solutions - Tennessee, LLC

Clinical Data

This intervention maps to 14 entities in the Ltrl knowledge graph.

9
Conditions
2
Biomarkers
1
Specialists
0
Symptoms
139
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.