Substance / Medication

Inebilizumab

Overview

Active Ingredient
inebilizumab
RxNorm CUI
2373951
Labeler: Horizon Therapeutics USA, Inc.Updated: 2025-12-11T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

UPLIZNA is contraindicated in patients with: Warnings and Precautions (5.1) [see] A history of a life-threatening infusion reaction to UPLIZNA Warnings and Precautions (5.2) [see] Active hepatitis B infection Warnings and Precautions (5.2) [see] Active or untreated latent tuberculosis

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Inebilizumab for Treatment of IgG4-Related Disease.
Stone John H, Khosroshahi Arezou, Zhang Wen et al. · N Engl J Med · 2025
PMID: 39541094RCT
A Phase 3 Trial of Inebilizumab in Generalized Myasthenia Gravis.
Nowak Richard J, Benatar Michael, Ciafaloni Emma et al. · N Engl J Med · 2025
PMID: 40202593RCT
Efficacy and safety of inebilizumab in Asian participants with neuromyelitis optica spectrum disorder: Subgroup analyses of the N-MOmentum study.
Fujihara Kazuo, Kim Ho Jin, Saida Takahiko et al. · Mult Scler Relat Disord · 2023
PMID: 37769428RCT
Inebilizumab for treatment of neuromyelitis optica spectrum disorder in patients with prior rituximab use from the N-MOmentum Study.
Flanagan Eoin P, Levy Michael, Katz Eliezer et al. · Mult Scler Relat Disord · 2022
PMID: 35158461RCT
AQP4-IgG-seronegative patient outcomes in the N-MOmentum trial of inebilizumab in neuromyelitis optica spectrum disorder.
Marignier Romain, Pittock Sean J, Paul Friedemann et al. · Mult Scler Relat Disord · 2022
PMID: 35158465RCT
Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD.
Cree Bruce Ac, Bennett Jeffrey L, Kim Ho Jin et al. · Mult Scler · 2021
PMID: 33538237RCTFull text (PMC)
A recalcitrant case of pemphigus treated with inebilizumab.
Bear Christina M, Djavid Amir Reza, Candela Braden · JAAD Case Rep · 2026
PMID: 41362865Case ReportFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Inebilizumab (substance)
SNOMED CT
879883007
UMLS CUI
C4519594
RxNorm CUI
2373951
Labeler
Horizon Therapeutics USA, Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.