Substance / Medication

Isosorbide

Overview

Active Ingredient
isosorbide
RxNorm CUI
6057

Indications

For the short-term reduction of intraocular pressure. May be used prior to and after intraocular surgery. May be used to interrupt an acute attack of glaucoma.

Labeler: Alcon Laboratories, Inc.Updated: 2006-03-23T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Well-established anuria Severe dehydration Frank or impending acute pulmonary edema Severe cardiac decompensation Hypersensitivity to any component of this preparation

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Isosorbide Mononitrate Versus Dinoprostone for Cervical Ripening During Labor Induction: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
Abu-Zaid Ahmed, Khadawardi Khalid, Al-Matary Abdulrahman et al. · Reprod Sci · 2023
PMID: 35441336Meta-Analysis
Misoprostol plus isosorbide mononitrate versus misoprostol alone for cervical ripening during labor induction: A systematic review and meta-analysis of randomized controlled trials.
Abuzaid Mohammed, Baradwan Saeed, Alkhamis Waleed H et al. · J Gynecol Obstet Hum Reprod · 2022
PMID: 34583026Meta-Analysis
Isosorbide mononitrate for cervical ripening during labour induction: A systematic review and meta-analysis of 23 randomized controlled trials.
Abu-Zaid Ahmed, Alshahrani Majed Saeed, Al-Matary Abdulrahman et al. · Eur J Obstet Gynecol Reprod Biol · 2022
PMID: 35803111Meta-Analysis
Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.
Borges Migliavaca Celina, Stein Cinara, Colpani Verônica et al. · PLoS Negl Trop Dis · 2018
PMID: 30265663Meta-AnalysisFull text (PMC)
[Beta-blockers plus isosorbide-5-mononitrate for prevention of esophageal variceal rebleeding: a systematic review].
Sun Xiao-Bin, Wang Qiong, Shi Wei · Zhonghua Gan Zang Bing Za Zhi · 2008
PMID: 18752758Meta-Analysis
Effects of Nicorandil, Isosorbide Mononitrate, or Diltiazem on Radial Artery Grafts After CABG: The Randomized ASRAB-Pilot Trial.
Zhu Yunpeng, Zhang Wei, Qin Kaijie et al. · Circ Cardiovasc Interv · 2025
PMID: 40123490RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Isosorbide (substance)
SNOMED CT
386853004
UMLS CUI
C0022251
RxNorm CUI
6057
Labeler
Alcon Laboratories, Inc.

Clinical Data

This intervention maps to 11 entities in the Ltrl knowledge graph.

4
Conditions
4
Biomarkers
2
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.