Substance / Medication

Ketoprofen

Overview

Active Ingredient
ketoprofen
RxNorm CUI
6142

Indications

Carefully consider the potential benefits and risks of ketoprofen capsules USP and other treatment options before deciding to use ketoprofen capsules USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.Ketoprofen capsules USP are indicated for the management of the signs and symptoms of rheumatoid arthritis and osteoarthritis.Ketoprofen capsules USP are indicated for the management of pain. Ketoprofen capsules USP are also indicated for

Labeler: Misemer Pharmaceuticals, Inc.Updated: 2026-02-15T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Cardiovascular Thrombotic Events Gastrointestinal Risk 1 Throughout this package insert, the term NSAID refers to a non-aspirin non-steroidal anti-inflammatory drug. Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardia

Contraindications

When this intervention should not be used

Ketoprofen capsules are contraindicated in patients who have shown hypersensitivity to ketoprofen.Ketoprofen capsules USP should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic reacti

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
The comparison of dexketoprofen and other painkilling medications (review from 2018 to 2021).
Kuczyńska Joanna, Pawlak Angelika, Nieradko-Iwanicka Barbara · Biomed Pharmacother · 2022
PMID: 35299123Meta-Analysis
Future prospects of ketoprofen in improving the safety of the gastric mucosa.
Kuczyńska Joanna, Nieradko-Iwanicka Barbara · Biomed Pharmacother · 2021
PMID: 33932737Meta-Analysis
The efficacy of dexketoprofen for migraine attack: A meta-analysis of randomized controlled studies.
Yang Baohua, Xu Zhili, Chen Linglong et al. · Medicine (Baltimore) · 2019
PMID: 31725614Meta-AnalysisFull text (PMC)
Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta-analysis.
Esparza-Villalpando Vicente, Pozos-Guillén Amaury, Masuoka-Ito David et al. · Drug Dev Res · 2018
PMID: 29243848Meta-Analysis
Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review.
Sardana Vandit, Burzynski Joanna, Zalzal Paul · Musculoskeletal Care · 2017
PMID: 27778435Meta-Analysis
Single dose oral ketoprofen or dexketoprofen for acute postoperative pain in adults.
Gaskell Helen, Derry Sheena, Wiffen Philip J et al. · Cochrane Database Syst Rev · 2017
PMID: 28540716Meta-AnalysisFull text (PMC)
Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults.
Barden Jodie, Derry Sheena, McQuay Henry J et al. · Cochrane Database Syst Rev · 2009
PMID: 19821407Meta-AnalysisFull text (PMC)
Systematic review of dexketoprofen in acute and chronic pain.
Moore R Andrew, Barden Jodie · BMC Clin Pharmacol · 2008
PMID: 18976451Meta-AnalysisFull text (PMC)
Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled Trial.
Pérez-González Fabián, Abusamak Mohammad, Ruiz Leire Virto et al. · Clin Exp Dent Res · 2026
PMID: 41510697RCTFull text (PMC)
Efficacy of Oral Paracetamol Compared with Oral Ketoprofen for Pain Management in Office Hysteroscopy: A Double-Blind, Randomized Clinical Trial.
Anggraeni Tricia Dewi, Widyatama Andika, Soetikno Vivian et al. · Medicina (Kaunas) · 2026
PMID: 41597456RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ketoprofen (substance)
SNOMED CT
386832008
UMLS CUI
C0022635
RxNorm CUI
6142
Labeler
Misemer Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 9 entities in the Ltrl knowledge graph.

4
Conditions
2
Biomarkers
1
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.